结核性脑膜炎患者抗结核治疗致药物性肝炎的临床发生率及治疗措施

Clinical Incidence and Treatment of Drug-induced Hepatitis Caused by Anti-tuberculosis Treatment in Patients with Tuberculous Meningitis

目的分析结核性脑膜炎患者抗结核治疗致药物性肝炎的发病规律以及与之对应的治疗措施。方法将我院2019年1月至2021年1月接受治疗的238例结核性脑膜炎患者作为研究对象,患者均接受抗结核治疗,观察患者年龄、服药时间、合并肺结核类型与发生药物性肝炎的关系,同时对患者的治疗效果进行观察。结果与<18岁、19-64岁相比,≥65岁的患者发生药物性肝炎的数例最多,有明显差异(P <0.05);服药2-8周时发生药物性肝炎的概率高于<2周、> 8周的药物性肝炎发生概率,有明显差异(P <0.05);合并血行播散型肺结核的脑膜炎患者,发生药物性肝炎的概率明显高于其他合并肺结核类型的概率,比较有明显差异,P <0.05。结论结核性脑膜炎患者在接受治疗过程中,容易出现药物性肝炎,因此需要给予患者科学有效的用药方案。

Objective To analyze the incidence of drug-induced hepatitis caused by anti-tuberculosis treatment in patients with tuberculous meningitis and the corresponding treatment measures.Methods Two hundred and thirty eight patients with tuberculous meningitis who were treated in our hospital from January 2019 to January 2021 were taken as the research objects.The patients all received anti-tuberculosis treatment.The age of the patients,the time of medication,the type of combined tuberculosis and the occurrence of drug resistance were observed.The relationship between hepatitis and the treatment effect of patients will be observed at the same time.Results Compared with<18 years old and 19-64 years old,the number of cases of drug-induced hepatitis occurred in patients≥65 years old,there was significantly different,P<0.05;the probability of drug-induced hepatitis occurring after taking the medicine for 2-8 weeks was higher than<2 weeks,The incidence of drug-induced hepatitis>8 weeks,there is a difference in the comparison of the three groups of medication time,P<0.05;the probability of drug-induced hepatitis in patients with hematogenous pulmonary tuberculosis is significantly higher than that of other types of pulmonary tuberculosis.There is a difference in comparison,P<0.05.Conclusion Patients with tuberculous meningitis are prone to drug-induced hepatitis during treatment,so it is necessary to give patients a scientific and effective medication regimen.