肝癌患者热消融介入治疗中MRI引导的效果对比

Comparison of the effect of MRI guidance in thermal ablation interventional therapy for patients with liver cancer

目的:探讨磁共振(MRI)引导在原发性肝癌(PLC)患者介入治疗中的临床效果及对肿瘤标志物的影响研究。方法:选取我院在2019年8月-2020年2月确诊并治疗的64例PLC患者,均接受热消融介入治疗,依据随机数字表法进行分组,对照组应用CT引导,研究组应用MRI引导。观察比较两组的治疗有效比率水平差异;两组的并发症;两组治疗前、治疗后的相关肿瘤标志物:甲胎蛋白(AFP)、糖蛋白抗原50(CA50)、糖蛋白抗原199(CA199)、特异性肿瘤生长因子(TSGF)水平变化及差异情况。结果:研究组有效比率水平比对照组高(P<0.05)。研究组胸腔积液及损伤肝功能比率比对照组低(P<0.05),两组血小板水平降低及发热比率无显著差异(P>0.05)。研究组治疗后的相关肿瘤标志物水平均比对照组低(P均<0.05)。结论:给予原发性肝癌患者在热消融介入治疗中应用MRI引导,可显著提高治疗有效率,安全性高,同时还能够显著降低患者的相关肿瘤标志物水平。

Objective:To investigate the clinical effect of magnetic resonance(MRI)guidance in interventional treatment of patients with primary liver cancer(PLC)and its influence on tumor markers.Methods:64 patients with PLC diagnosed and treated in our hospital from August 2019 to February 2020 were selected and received thermal ablation interventional therapy.They were grouped according to the random number table method.The control group was guided by CT and the study group was guided by MRI..Observe and compare the difference in the effective rate of treatment between the two groups;the complications of the two groups;the relevant tumor markers of the two groups before and after treatment:alpha-fetoprotein(AFP),glycoprotein antigen 50(CA50),glycoprotein antigen 199(CA199),specific tumor growth factor(TSGF)level changes and differences.Results:The effective ratio of the study group was higher than that of the control group(P<0.05).The ratio of pleural effusion and damaged liver function in the study group was lower than that in the control group(P<0.05),and there was no significant difference in the reduction of platelet level and fever ratio between the two groups(P>0.05).The level of relevant tumor markers in the study group after treatment was lower than that in the control group(all P<0.05).Conclusion:The application of MRI guidance in thermal ablation interventional therapy for patients with primary liver cancer can significantly improve the treatment efficiency and safety,and it can also significantly reduce the level of relevant tumor markers in patients.