盐酸氨溴索治疗慢性支气管炎急性发作的疗效观察

Therapeutic Effect of Ambroxol Hydrochloride on Acute Attack of Chronic Bronchitis

目的分析盐酸氨溴索治疗慢性支气管炎急性发作的临床效果。方法选取法库县中心医院(时间为2017年8月至2018年8月)接收慢性支气管炎急性发作患者100例为研究对象。研究中按照随机数表分组方法将患者分为对照组(n=50,在常规方法基础上应用莫西沙星治疗)和观察组(n=50,使用盐酸氨溴索治疗)。对比分析两组患者临床效率。结果统计两组患者临床效率,对照组明显低于观察组(78.00%vs.98.00%)(P<0.05);两组患者治疗前PaO2与PaCO2无差异(P>0.05);治疗后患者上述两项指标均改善,且观察组患者改善效果优于对照组(P<0.05);观察组患者痰量减少、喘息缓解、肺部湿啰音及咳嗽缓解等各项症状消失时间均短于对照组(P<0.05)。结论对慢性支气管炎急性发作期间的患者使用盐酸氨溴索,可提高临床治疗效率,改善患者血气指标,同时还能够在较短时间缓解患者的各项症状,其临床应用效果显著。

Objective To analyze the clinical effect of ambroxol hydrochloride on acute attack of chronic bronchitis.Methods From August 2017 to August 2018,100 patients with acute attack of chronic bronchitis were admitted to Faku County Central hospital.In the study,patients were divided into control group and observation group according to the random number table grouping method,with 50 patients in both groups.The control group was treated with moxifloxacin on the basis of conventional methods,and the observation group was treated with ambroxol hydrochloride.The clinical efficiency of the two groups was compared and analyzed.Results Statistics of the clinical efficiency of the two groups of patients,the control group was significantly lower than the observation group(78.00%vs.98.00%)(P<0.05);there was no difference between the two groups of patients in PaO_(2) and PaCO_(2) before treatment(P>0.05);after treatment the above two the indicators were improved,and the improvement effect of patients in the observation group was better than that in the control group(P<0.05);the disappearance time of various symptoms such as decreased sputum volume,relief of wheezing,pulmonary rales and cough relief in the observation group was shorter than that of the control group(P<0.05).Conclusion Ambroxol hydrochloride treatment during acute attack of chronic bronchitis can improve the efficiency of clinical treatment,improve the blood gas index of patients,and also alleviate the symptoms of patients in a relatively short time.The clinical application effect is remarkable.