丁苯酞联合尼莫地平序贯疗法治疗脑出血44例效果观察

The Effect of Sequential Therapy of Butylphthalide Combined with Nimodipine on 44 Cases of Cerebral Hemorrhage

目的:观察脑出血患者应用丁苯酞联合尼莫地平序贯疗法的治疗效果。方法:收集2019年3月至2020年3月期间河南科技大学第一附属医院收治的脑出血患者88例,按随机数字表法分为对照组和观察组,每组44例。对照组采用尼莫地平序贯治疗,观察组在对照组基础上联合丁苯酞治疗,比较两组血肿体积、认知评分、生活能力评分及血液动力学指标水平变化情况。结果:治疗前,两组血肿体积、认知评分、生活能力评分、外周阻力、平均血流量及平均血流速度无统计学意义(P>0.05);治疗后,观察组血肿体积显著小于对照组(P<0.05);观察组认知评分、生活能力评分显著优于对照组(P<0.05);观察组外周阻力、平均血流量及平均血流速度显著优于对照组(P<0.05)。结论:在脑出血患者中应用丁苯酞联合尼莫地平序贯疗法治疗能显著改善机体血液动力学异常水平,减少血肿发生,提高患者生理能力。

Objective:To observe the sequential effect of butylphthalide combined with nimodipine in patients with cerebral hemorrhage.Methods:88 patients with cerebral hemorrhage admitted to The First Affiliated Hospital of Henan University of Science and Technology from March 2019 to March 2020 were divided into control group and observation group,44 cases in each group.The control group was treated with nimodipine sequential treatment,and the observation group was treated with butylphthalide on the basis of the control group.The changes of hematoma volume,cognitive score,life ability score and hemodynamic indexes were compared between the two groups.Results:Before treatment,the hematoma volume,cognitive score,lifestyle score,peripheral resistance,mean blood flow,and mean flow velocity were not statistically significant(P>0.05);the observed group was significantly smaller than the control group(P<0.05),cognitive score was significantly better than the control group(P<0.05);and peripheral resistance,mean blood flow,and mean flow velocity were significantly better than the control group(P<0.05).Conclusion:Butylphthalide combined with nimodipine can significantly improve the level of abnormal hemodynamics,reduce the incidence of hematoma and improve the physiological ability of patients with cerebral hemorrhage.