银杏达莫联合阿托伐他汀治疗急性缺血性脑卒中伴2型糖尿病40例分析

Clinical Effect and Safety of Ginkgo-damole Combined with Atorvastatin in the Treatment of Acute Cerebral Ischemic Stroke Combined with T2DM

目的:观察阿托伐他汀联合银杏达莫治疗急性缺血性脑卒中(CIS)伴2型糖尿病(T2DM)的临床效果。方法:依据随机数字表法将2017年8月至2020年7月萍乡矿业集团有限责任公司总医院收治的80例急性CIS伴T2DM患者分成观察组、对照组各40例。对照组予以阿托伐他汀,观察组予以阿托伐他汀联合银杏达莫。根据治疗前后美国国立卫生研究院卒中量表(NIHSS)结果比较两组疗效;检测甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(FIB)、血浆黏度、全血高切黏度、红细胞比容(PCV)等血脂及血液流变学指标;观察治疗期间不良反应。结果:治疗后观察组总有效率、HDL-C高于对照组(P<0.05),TG、TC、LDL-C、FIB、血浆黏度、全血高切黏度、PCV低于对照组(P<0.05);治疗期间两组未见明显药物不良反应。结论:阿托伐他汀联合银杏达莫治疗急性CIS合并T2DM患者疗效明显,可以降低血脂、缓解血液黏稠状态。

Objective:To observe the clinical curative effect of atorvastatin combined with ginkgo-damole on acute cerebral ischemic stroke(CIS)combined with type 2 diabetes mellitus(T2DM).Methods:According to random number table method,80 patients with acute CIS and T2DM admitted to the hospital from August 2017 to July 2020 were divided into observation group and control group,40 cases in each group.The control group was given atorvastatin,while observation group was given atorvastatin combined with ginkgo-damole.The curative effect between the two groups was compared by scores of National Institutes of Health Stroke Scale(NIHSS)before and after treatment.The levels of blood lipid and hemorheology indexes[triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),fibrinogen(FIB),plasma viscosity,whole blood high-shear viscosity,packed cell volume(PCV)]were detected.The adverse reactions during treatment were recorded.Results:After treatment,total response rate and HDL-C in observation group were higher than those in control group(P<0.05),TG,TC,LDL-C,FIB,plasma viscosity,whole blood high-shear viscosity and PCV were lower than those in control group(P<0.05).There were no significant adverse drug reactions during treatmentin either group.Conclusion:The curative effect of atorvastatin combined with ginkgo-damole is significant on patients with acute CIS and T2DM,which can reduce blood lipid and relieve blood viscosity.