中医药调节结直肠癌免疫微环境的研究进展

Research progress of traditional Chinese medicine regulating immune microenvironment of colorectal cancer

结直肠癌是临床常见的恶性肿瘤,目前治疗方式主要包括手术、放疗、化疗及靶向治疗,随着免疫检查点抑制剂的临床应用,结直肠癌进入了免疫治疗时代。中医药作为肿瘤综合治疗的一部分,在结直肠癌的治疗中运用广泛。中医药对结直肠癌免疫微环境的调节是其发挥治疗作用的主要途径之一,主要表现在调节T细胞介导的适应性免疫及固有免疫细胞介导的免疫反应。从免疫微环境对结直肠癌发生发展的影响、中医药调节结直肠癌免疫微环境等方面进行综述,以期为中医药参与的肿瘤免疫治疗研究提供思路。

Colorectal cancer is a common malignant tumor in clinic.At present,the treatment methods mainly include surgery,radiotherapy,chemotherapy and targeted therapy.With the clinical application of immune checkpoint inhibitors,the therapy for colorectal cancer has entered the era of immunotherapy.As a part of comprehensive treatment on cancer,traditional Chinese medicine is widely used in the treatment of colorectal cancer.The regulation of traditional Chinese medicine on the immune microenvironment of colorectal cancer is one of the main ways to play its therapeutic role,which mainly manifests in the regulation of adaptive immunity mediated by T cells and immune response mediated by innate immune cells.This paper reviews the influence of immune microenvironment on the occurrence and development of colorectal cancer,as well as the regulation of traditional Chinese medicine on the immune microenvironment of colorectal cancer,so as to provide ideas for the research of tumor immunotherapy with traditional Chinese medicine.