乳双歧杆菌LGG-08发酵酸奶润肠通便和调节肠道菌群的作用

Effect of Bifidobacterium Lactis LGG-08 Fermented Yoghurt on Bowel Defecation and Regulation of Intestinal Flora

益生菌具有缓解便秘和调节肠道菌群的作用,但菌株具有特异性。本研究旨在评价乳双歧杆菌LGG-08发酵酸奶的润肠通便和调节肠道菌群的作用。招募便秘受试者50人,饮用LGG-08发酵酸奶28d,饮用结束后分析受试者便秘相关症状和肠道菌群多样性的变化情况。与排空期相比,LGG-08酸奶干预14d后,受试者排便次数显著增加(P<0.0001),排便不畅比例、排便时长显著降低(P<0.001),排便状况积分和粪便性状积分显著改善,且饮用28d,排便不畅和排便状况改善效果更佳。另外,干预14d和28d后,肠道中纺锤链杆属(Fusicatenibacter)和凸腹真杆菌属(Eubacterium_ventriosum_group)相对丰度显著降低,干预28d,魏斯氏菌属(Weissella)相对丰度显著增加,LGG-08发酵酸奶对便秘的改善作用可能与这些菌的变化相关。本研究为开发婴儿源乳双歧杆菌LGG-08相关功能食品提供了理论依据。

Probiotics have the function of relieving constipation and regulating intestinal flora,but the strain has specificity.The aim of this study was to evaluate the effects of Bifidobacterium lactis LGG-08(LGG-08)fermented yoghurt on relaxing bowels and regulating intestinal microbiota.50 Constipation subjects were recruited and drank LGG-08 fermented yoghurt for 28 days.After drinking,the constipation-related symptoms and changes in intestinal microbiota diversity of the subjects were analyzed.Compared with the baseline period,after 14 days of intervention,the number of defecation of subjects significantly increased(P<0.0001),the proportion of poor defecation,the duration of defecation significantly decreased(P<0.001),the defecation status score and fecal character volume significantly improved,and after 28 days of drinking,the improvement effect of poor defecation and defecation status was better.In addition,after 14 and 28 days of intervention,the relative abundance of Fusicatenibacter and Eubacterium_ventriosum_group decreased significantly;after 28 days of intervention,the relative abundance of Weissella increased significantly.The improvement effect of LGG-08 fermented yoghurt on constipation may be related to the change of these bacteria.This study provides a theoretical basis for the development of functional food related to Bifidobacterium lactis LGG-08 from infants.