喹硫平联合认知行为疗法治疗精神分裂症对照研究

A controlled study of quetiapine combined with behavioral cognitive therapy in the treatment of schizophrenia

目的探讨喹硫平联合认知行为疗法治疗精神分裂症患者的临床疗效。方法将98例精神分裂症患者按随机数字表法分为两组,各49例。两组均予以喹硫平治疗,观察组在此基础上联合认知行为疗法治疗,观察24周。比较两组临床疗效,治疗前后阳性与阴性症状量表、威斯康星卡片分类测验评分,随访6个月统计复发率。结果观察组总有效率显著高于对照组(P<0.05)。治疗后观察组阳性与阴性症状量表的阳性症状、阴性症状评分显著低于对照组(P<0.01),威斯康星卡片分类测验的正确分类数、正确应答数显著多于对照组(P<0.01),错误应答数显著少于对照组(P<0.01)。随访6个月末,观察组复发率显著低于对照组(P<0.05)。结论喹硫平联合认知行为疗法治疗精神分裂症疗效确切,可显著改善临床症状,增强患者的认知功能,降低复发率。

Objective To investigate the curative effect of quetiapine combined with behavioral cognitive therapy in the treatment of schizophrenia.Methods A total of 98 patients with schizophrenia were divided into a study group(49 cases)and a control group(49 cases)according to the random number table method.The control group was treated with quetiapine treatment,and the study group was treated with behavioral cognitive therapy on this basis for 24 weeks.The clinical efficacy,positive and negative symptom scale(PANSS)score and Wisconsin card sorting test(WCST)score before and after treatment were compared between the two groups.The recurrence rate was counted after 6 months of follow-up.Results The total effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,the scores of positive and negative symptoms of PANSS in the study group were significantly lower than those in the control group(P<0.01).The number of correct classification and correct answers of WCST was significantly more than that of the control group(P<0.01),and the number of wrong answers was significantly less than that of the control group(P<0.01).At the end of the 6-month follow up,the recurrence rate of the study group was significantly lower than that of the control group(P<0.05).Conclusions Quetiapine combined with behavioral cognitive therapy has a definite effect in the treatment of schizophrenia,which can significantly improve clinical symptoms,enhance patients'cognitive function,and reduce the recurrence rate.