牙周基础治疗对2型糖尿病合并慢性牙周炎患者糖脂代谢及炎症反应的影响

Effects of Periodental Non-surgical Treatment on Glycolipid Metabolism and Inflammatory Response in Patients with Type 2 Diabetes Mellitus Complicated with Chronic Periodontitis

目的:探讨牙周基础治疗对2型糖尿病(Type 2 diabetes mellitus,T2DM)合并慢性牙周炎患者糖脂代谢及炎症反应的影响。方法:按照随机数字表法将2019年1月-2019年12月笔者医院收治的150例T2DM合并慢性牙周炎患者分为对照组与观察组,每组75例。对照组患者进行糖尿病常规治疗,观察组患者在糖尿病常规治疗的基础上进行牙周基础治疗,均连续治疗3个月。比较两组糖代谢指标[空腹血糖(Fasting blood-glucose,FBG)、餐后2h血糖(2h postprandial blood glucose,2hPG)、糖化血红蛋白(Glycosylated hemoglobin,HbA1c)],脂代谢指标[总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、低密度脂蛋白(Low density lipoprotein,LDL)、高密度脂蛋白(High density lipoprotein,HDL)]及炎症因子[肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-1β(Interleukin-1β,IL-1β)、IL-6、IL-10]的变化。结果:治疗后,观察组的FBG[(5.99±0.40)mmol/L vs(6.87±0.80)mmol/L]、2hPG[(7.41±0.46)mmol/L vs(8.93±0.90)mmol/L]、HbA1c[(6.45±0.58)%vs(7.84±0.66)%]水平均明显低于对照组(P<0.05);观察组的TG[(0.98±0.22)mmol/L vs(2.20±0.79)mmol/L]水平明显低于对照组(P<0.05);观察组的TNF-α[(1.15±0.32)pg/ml vs(2.87±0.65)pg/ml]、IL-1β[(0.40±0.15)pg/ml vs(3.71±0.94)pg/ml]水平明显低于对照组(P<0.05),IL-10[(11.25±1.44)pg/ml vs(7.82±1.90)pg/ml]水平明显高于对照组(P<0.05)。结论:牙周基础治疗对T2DM合并慢性牙周炎患者的糖脂代谢及炎症反应具有明显的改善作用。

Objective To discuss the effects of periodental non-surgical treatment on glycolipid metabolism and inflammatory response in patients with type 2 diabetes mellitus(T2DM)complicated with chronic periodontitis.Methods According to the random number method,150 patients with T2DM complicated with chronic periodontitis who were divided into control group and observation group in our hospital from January to December 2019,with 75 cases in each group.All patients were treated continuously for 3 months.The glucose metabolism indicators[fasting blood glucose(FBG),2 h postprandial blood glucose(2 HPG),glycosylated hemoglobin(HbA1c)],lipid metabolism indicators[total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL)]and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6,IL-10].Results After treatment,the level of FBG[(5.99±0.40)mmol/L vs(6.87±0.80)mmol/L],2hPG[(7.41±0.46)mmol/L vs(8.93±0.90)mmol/L],HbA1c[(6.45±0.58)%vs(7.84±0.66)%]in observation group was significantly lower than that in control group(P<0.05).The level of TG[(0.98±0.22)mmol/L vs(2.20±0.79)mmol/L]in observation group was significantly lower than that in control group(P<0.05).The level of TNF-α[(1.15±0.32)pg/ml vs(2.87±0.65)pg/ml],IL-1β[(0.40±0.15)pg/ml vs(3.71±0.94)pg/ml]in observation group was significantly lower than that in control group and the level of IL-10[(11.25±1.44)pg/ml vs(7.82±1.90)pg/ml]in observation group was significantly higher than that in control group(P<0.05).Conclusion Periodental non-surgical treatment could significantly improve the glycolipid metabolism and inflammatory response in patients with glycolipid metabolism and inflammatory response in patients with T2DM complicated with chronic periodontitis.