摘要
间充质干细胞主要通过免疫调控和旁分泌在炎症性疾病的治疗中发挥功能。MSC的旁分泌效应是通过分泌可溶性因子并释放外泌体而发挥作用。外泌体将DNA、蛋白质/肽、mRNA、microRNA、脂质和细胞器等成分转移到受体细胞中直接发挥功能。MSC-Exo替代MSC为炎症性肠病的治疗提供了一种新策略。总结不同组织(骨髓、脐带和脂肪)来源的MSC-Exo用于治疗炎症性肠病的研究进展。
Mesenchymal stem cells(MSC)play an important role in the treatment of inflammatory diseases through immune regulation and paracrine effect.The paracrine effect of MSC is mediated by secreting soble factors and releasing exosomes(Exo).Exosomes transfer DNA,proteins/peptides,mRNA,microRNA,lipids and organelles into recipient cells and display functions directly.Therefore,MSC-Exo instead of MSC provides a new strategy for the treatment of inflammatory bowel diseases.In this review,we summarize the progress of MSC-Exo derived from various tissues(bone marrow,umbilical cord and adipose)for the treatment of inflammatory bowel diseases.
作者
李开秀
司维
LI Kai-xiu;SI Wei(Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650504,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2021年第7期66-73,共8页
China Biotechnology
基金
国家自然科学基金(31872973)资助项目。
关键词
间充质干细胞
外泌体
炎症性肠病
Mesenchymal stem cells
Exosomes
Inflammatory bowel disease
