MiR-148生物学功能研究进展

Research Progress on the Biological Function of MiR-148

microRNA(miRNA)是一种分布广泛、功能多样、在物种间高度保守的非编码单链RNA。miRNA可通过与目标mRNA的3'非编码区(3'UTR)完全或不完全靶向结合来调控基因的表达,在转录水平发挥调控作用。miRNA以稳定的形式存在于各种体液中,可作为不同生理或病理状态下的生物标志物。基于前期高通量测序发现miR-148在猪初乳与常乳外泌体中差异表达,拟从免疫、肿瘤及其他生物学功能,综述miR-148相关研究进展,以期为乳汁外泌体运载miR-148发挥生物学功能的研究提供参考。

MicroRNA(miRNA)is a non-coding single-stranded RNA that is widely distributed,diverse in functions,and highly conserved among species.MiRNA can regulate gene expression by completely or incompletely targeting the 3'non-coding region(3'UTR)of target mRNA,and play a regulatory role at the transcriptional level.At the same time,miRNA exists in various body fluids in a stable form,and can be used as a biomarker under different physiological or pathological conditions.Based on the early high-throughput sequencing found that miR-148 is differentially expressed in porcine colostrum and normal milk exosomes,this article intends to review the progress of miR-148 related research in terms of immunity,tumors and other biological functions,with the hope that it provides reference for the study on the biological functions of miR-148 carried by exosomes.