孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的效果

Clinical efficacy of montelukast sodium combined with budesonide on children with cough variant asthma

目的:探讨孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的效果。方法:回顾性纳入信阳市中医院儿科2018年1月至2019年12月收治的小儿咳嗽变异性哮喘患儿230例为研究对象。根据用药方式分为布地奈德治疗组(112例)和孟鲁司特钠联合布地奈德治疗组(118例)。比较两组患儿的治疗效果、肺功能指标、炎症因子水平及不良反应发生情况。结果:治疗4周后,孟鲁司特钠联合布地奈德治疗组治疗总有效率(96.6%)高于布地奈德治疗组(79.6%),P<0.05;治疗后孟鲁司特钠联合布地奈德治疗组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC比值、动脉血氧饱和度(SaO_(2))较布地奈德治疗组(P<0.05),血清白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平低于布地奈德治疗组(P<0.05)。孟鲁司特钠联合布地奈德治疗组不良反应发生率高于布地奈德治疗组,但差异未见统计学意义(P>0.05)。结论:孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘疗效显著,有助于改善患儿肺功能,有效控制炎症,不良反应发生率低,安全性高。

Objective To explore the clinical efficacy of montelukast combined with budesonide on children with cough variant asthma.Methods A total of 230 children with cough variant asthma admitted to the Department of Pediatrics of Xinyang Traditional Chinese Medicine Hospital from January 2018 to December 2019 were selected as the research objects,and they were divided into budesonide treatment group and montelukast sodium combined with budesonide treatment group according to medication methods.The curative effect,lung function index and inflammatory factor level and adverse reaction of the two groups were compared.Results After 4 weeks of treatment,the total effective rate of montelukast combined with budesonide treatment group(96.6%)was higher than that of budesonide treatment group(79.6%),P<0.05.After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC ratio,arterial oxygen saturation(SaO2)in montelukast sodiumcombined with budesonide treatment group were higher than those in budesonide treatment group(P<0.05),the levels of serum interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)in montelukast sodiumcombined with budesonide treatment group were lower than those in budesonide treatment group(P<0.05).The adverse reaction rate of montelukast sodiumcombined sodium with budesonide group was higher than that of budesonide group,but there was no significant difference(P>0.05).Conclusions Montelukast sodiumcombined with budesonide is effective in the treatment of cough variant asthma in children.It is helpful to improve the lung function of children,effectively control inflammation,and with low incidence of adverse reactions and high safety.