IF-17在肝细胞癌发病机制研究中的进展

Progress of IF-17 in the pathogenesis of hepatocellular carcinoma

IL-17是已发现的30余种白细胞介素之一,在多种生物进程中发挥重要作用。在正常情况下,IL-17可以导致炎症的发生。但在病理条件下,IL-17对多种肿瘤也具有促进作用。肝细胞癌是肝癌中最常见的一种类型,发展快、预后差、易转移,且肿瘤微环境中有明显的炎症反应,这些生物学特性提示肝癌的发生、发展与IL-17的表达有一定的关系。IL-17可以通多种途径来影响肝细胞癌的生长、发展和自噬。如通过AKT/IL-6/JAK2/STAT3信号通路和miR-383/STAT3轴促进肝细胞癌生长、通过激活NF-κB信号通路增加基质金属蛋白酶的表达来促进肝细胞癌转移、通过NF-κB途径增强PIAS1的表达来抑制IFN-γ的抗肿瘤作用,以及通过抑制Bcl2-Beclin1中的Bcl2降解来抑制肝细胞癌细胞的自噬。本文就IL-17在肝细胞癌中发病机制的研究状况作一综述。

IL-17 is one of more than 30 kinds of interleukin,which plays an important role in many biological processes.Under normal circumstances,IL-17 can cause inflammation.However,under pathological conditions,IL-17 can also promote a variety of tumors.Hepatocellular carcinoma(HCC)is the most common type of liver cancer.It has rapid development,poor prognosis,easy metastasis,and obvious inflammatory reaction in tumor microenvironment.These biological characteristics suggest that the occurrence and development of HCC are related to the expression of IL-17.IL-17 can affect the growth,development and autophagy of hepatocellular carcinoma through a variety of ways.For example,promot the growth of hepatocellular carcinoma through the AKT/IL-6/JAK2/STAT3 signaling pathway and the miR-383/STAT3 axis,increase the expression of MMPs by activating the NF-κB signaling pathway to promote hepatocellular carcinoma metastasis,enhance the expression of PIAS1 through the NF-κB pathway to inhibit the anti-tumor effect of IFN-γ,and by inhibiting the degradation of Bcl2 in Bcl2-Beclin1 to inhibit autophagy of hepatocellular carcinoma cells.This article reviews the research status of IL-17 in the pathogenesis of hepatocellular carcinoma.