基于治疗药物监测的注射用美罗培南省集采和进口品种的临床应用实践分析

Clinical application of meropenem for injection collected and imported varieties based on therapeutic drug monitoring

目的比较在相同人群和相同给药方案时,注射用美罗培南省集采和进口品种的血浆药物浓度的差异。方法通过检验系统和电子病历系统收集2019—2020年进行美罗培南血浆药物浓度监测的患者资料,按年龄、肾功能和给药方案进行分组,用SPSS 25软件对美罗培南血浆药物浓度结果进行统计学分析。结果按患者年龄和肾小球滤过率分组,相同人群在相同给药方案时,美罗培南省集采和进口品种血浆药物浓度结果差异均无统计学意义。结论从美罗培南血浆药物浓度分析,注射用美罗培南省集采品种和进口品种差异无统计学意义,应按正常剂量使用。

Objective To determine whether there is statistical difference in the plasma concentrations of collected and imported meropenem for injection in the same population with the same medication regimen.Methods The data of patients with meropenem plasma concentrations from 2019 to 2020 were collected by the AutoLis system and electronic medical record.The patients were grouped according to age,renal function and medication regimen.The results of meropenem plasma concentrations were analyzed by SPSS 25.Results The patients were grouped according to age and glomerular filtration rate.There was no statistical difference in the meropenem plasma concentration between collected and imported varieties in the same population with the same medication regimen.Conclusion There is no difference in the plasma concentrations between imported and collected meropenem for injection.