肝胆手术后胆漏的临床治疗分析

Clinical Analysis of Bile Leakage after Hepatobiliary Surgery

目的探讨肝胆手术后胆漏的临床治疗方法及效果。方法选取2008年3月至2020年3月我院收治的54例肝胆手术后胆漏患者,随机分为两组,对照组进行常规治疗,研究组进行针对性治疗。比较两组治疗结果、生活质量、炎性因子水平、总胆红素、谷氨酰转肽酶、白细胞计数。结果与对照组比较,研究组手术、下床活动、住院天数、肛门排气时间更短,手术出血量更少(P<0.05);治疗前,两组生活质量评分没有明显差异,治疗后,与对照组比较,研究组生活质量评分更高(P<0.05);与对照组比较,研究组总胆红素、谷氨酰转肽酶、白细胞计数更低(P<0.05);与对照组比较,研究组肿瘤坏死因子α、白细胞介素、C反应蛋白水平更低(P<0.05)。结论对肝胆手术后胆漏患者进行针对性治疗,效果理想,可改善患者生活质量与炎性因子水平,维持正常胆红素、谷氨酰转肽酶、白细胞计数,能够缩短治疗及住院时间,有利于降低患者经济及心理压力。因此,该治疗方法值得在临床上广泛应用。

Objective To investigate the clinical treatment and effect of bile leakage after hepatobiliary surgery.Methods 54 patients with bile leakage after hepatobiliary surgery in our hospital from March 2008 to March 2020 were selected and randomly divided into two groups.The control group received conventional treatment,and the study group received targeted treatment.The treatment results,quality of life,levels of inflammatory factors,total bilirubin,glutamyl transpeptidase and white blood cell count were compared between the two groups.Results Compared with the control group,the operation,out of bed activities,hospitalization days,anal exhaust time of the study group were shorter,and the amount of bleeding was less (P<0.05);before treatment,there was no significant difference in the quality of life score between the two groups,but after treatment,compared with the control group,the quality of life score of the study group was higher (P<0.05);compared with the control group,the total bilirubin,glutamyl transpeptidase,leukocyte count of the study group were lower Compared with the control group,the levels of tumor necrosis factor-α,interleukin and C-reactive protein in the study group were lower (P<0.05).Conclusion The effect of targeted treatment for patients with bile leakage after hepatobiliary surgery is ideal.It can improve the quality of life and the level of inflammatory factors,maintain normal bilirubin,glutamyltranspeptidase and white blood cell count,shorten the treatment and hospitalization time,and reduce the economic and psychological pressure of patients.Therefore,this treatment method is worthy of wide application in clinic.