2019年长春市乙型肝炎及其相关疾病的疾病负担分析

Burden of hepatitis B related diseases in Changchun City,Jilin Province,China in 2019

目的了解2019年长春市乙型肝炎及其相关疾病(肝硬化和肝癌)的疾病负担情况。方法通过《中国疾病预防控制信息系统》、《人口死亡信息登记系统》等相关数据,运用早逝所致的寿命损失年(years of life lost,YLLs)和失能引起的寿命损失年(years of lived with disability,YLDs)评价乙型肝炎、肝硬化和肝癌患者的疾病负担情况。结果2019年长春市因乙型肝炎、肝硬化和肝癌损失的健康生命年分别为7697.50、2319.90和12723.7 DALYs(disability adjusted life years,伤残调整寿命年);YLLs由高到低依次为肝癌、肝硬化和乙型肝炎,分别为12621.40、2210.60和766.40,而YLDs则相反,由高到低依次为乙型肝炎、肝硬化和肝癌,分别为6921.10、109.2和102.4。除乙型肝炎外,肝硬化和肝癌的DALYs主要由YLLs构成,男性略低于女性。30<50人群乙肝和50岁以上人群肝癌患者的疾病负担一直处于较高状态,DALYs均维持在3000以上。结论2019年长春市乙肝肝癌的疾病负担最重,乙型肝炎次之,乙肝肝硬化较轻,与国内其他地区持平,高于全球平均水平。

Objective To understand the burden of hepatitis B related diseases(hepatitis B,cirrhosis and liver cancer)in Changchun City,Jilin Province,China in 2019.Methods The burdens of hepatitis B,cirrhosis and liver cancer were evaluated with the data from China Disease Prevention and Control Information System and Population Death Information Registration System by using the Years of Life Lost(YLLs)caused by early death and the Years of Lived with Disability(YLDs).Results In 2019,the DALYs(disability adjusted life years)due to hepatitis B,cirrhosis and liver cancer in Changchun were 7697.50,2319.90 and 12723.7,while the YLLs were 766.40,2210.60 and 12621.40,and the YLDs were 6921.10,109.2 and 102.4,respectively.The DALYs due to cirrhosis and liver cancer were mainly composed of YLLs,which was slightly lower in male than in female.The burdens of hepatitis B in the population a ages of30~less than 50 years and liver cancer in those at not less than 50 years were higher than those in other age groups,while DALYs were more than 3000.Conclusion The burden of hepatitis B-related liver cancer in Changchun in 2019 was the heaviest,followed by that of hepatitis B,and that of cirrhosis was relatively light,which was equal to that in other regions in China and higher that the mean level in the world.