氧化低密度脂蛋白在动脉粥样硬化性心血管疾病诊断中的作用

Role of oxidized low density lipoprotein in the diagnosis of atherosclerotic cardiovascular disease

氧化低密度脂蛋白(oxLDL)作为致动脉粥样硬化(AS)的关键分子,在损伤血管内皮细胞,促进单核细胞黏附,诱导泡沫细胞和血栓形成等方面发挥着至关重要的作用。随着研究的深入,发现oxLDL能够作为循环生物标志物,用于AS及其相关疾病的诊断。该文阐述oxLDL在AS发生发展中的作用机制及其作为AS相关疾病的诊断标志物的研究进展。

As a critical factor of atherosclerosis(AS),oxidized low-density lipoprotein(oxLDL)plays a crucial role in damaging vascular endothelial cells,promoting monocyte adhesion,inducing formation of foam cells and thrombosis.Many scholars have found that oxLDL could be used as a circulating biomarker for atherosclerotic cardiovascular disease.In this manuscript,research progress on the mechanism of oxLDL in the initiation and development of atherosclerosis,as well as using oxLDL as a diagnostic biomarker of atherosclerosis related diseases were systemically reviewed.