生长分化因子-15在心血管疾病中的研究进展

Research progress of growth differentiation factor-15 in disease of cardiovascular system

生长分化因子15(GDF-15)是转化生长因子-β(TGF-β)超家族的一个远支。其在心血管疾病的发生发展过程中具有一定的生理作用和临床意义,不仅可作为心血管疾病发生及进展的生物标志物,而且对于疾病的风险分层及远期预后亦具有一定意义。通过回顾GDF-15在心血管疾病方面的临床研究及基础实验,阐述GDF-15在动脉粥样硬化、急性冠状动脉综合征等心血管疾病的最新研究进展,以期为临床在疾病诊治过程中对生物标志物的选择提供依据。

Growth differentiation factor-15(GDF-15)is a distant branch of the transforming growth factor-β(TGF-β)superfamily.Recent studies indicate that GDF-15 plays important physiological roles and has clinical implication in the initiation and development of various cardiovascular diseases.GDF-15 can both be used as a biomarker for the evaluation of cardiovascular disease occurrence and progression and a predictor for the risk stratification and long-term prognosis of cardiovascular diseases.The purpose of this review is to illustrate the latest research progress of GDF-15 in atherosclerosis and acute coronary syndrome obtained through the clinical research and basic experiments in cardiovascular diseases,to provide evidence for the selection of GDF-15 as useful biomarkers in the diagnosis and treatment of cardiovascular diseases.