摘要
Brain cancer,also known as intracranial cancer,is one of the most invasive and fatal cancers affecting people of all ages.Despite the great advances in medical technology,improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier(BBB).Fortunately,recent endeavors using gold-based nanomaterials(GBNs)have indicated the potential of these materials to cross the BBB.Therefore,GBNs might be an attractive therapeutic strategy against brain cancer.Herein,we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment.Furthermore,the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized,with an emphasis on the mechanism of their effective BBB penetration.Finally,the challenges and future outlook in using GBNs for brain cancer treatment are discussed.We hope that this review will spark researchers'interest in constructing more powerful nanoplatforms for brain disease treatment.
基金
supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.82001959 and 31630027)
NSFC-German Research Foundation(DFG)project(Grant No.31761133013)
appreciate support from the“Ten Thousand Elite Plan”(Grant No.Y9E21Z11)
CAS International Collaboration Plan(Grant No.E0632911ZX)
the National Key Research&Development Program of China(Grant No.2018YFE0117800)
the Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety
CAS(Grant No.NSKF202003)
Fujian Provincial Key Laboratory of Innovative Drug Target Research(Grant No.FJ-YW-2021KF04)
financial support from the Nanqiang Outstanding Young Talents Program from Xiamen University。
