中药三联疗法治疗儿童特应性皮炎78例临床观察

Clinical observation on triple therapy with Chinese materia medica for 78 cases of atopic dermatitis in children

目的观察妇安消疹洗液、玉屏风颗粒、白及多糖乳膏三联疗法治疗儿童特应性皮炎的临床疗效。方法选取十堰市太和医院(湖北医药学院附属医院)皮肤病中心2017年1月至2018年12月收治的儿童特应性皮炎156例,采用随机数字表法分为对照组和治疗组,各78例。对照组予玉屏风颗粒口服、白及多糖乳膏和氧化锌糊外涂患处,治疗组予玉屏风颗粒口服、白及多糖乳膏外涂患处、妇安消疹洗液涂擦患处,2组均1周为1个疗程,连续治疗4个疗程后统计临床疗效。结果对照组总有效率为84.6%(66/78),治疗组为100.0%(78/78),2组比较,差异有统计学意义(P<0.05)。治疗前2组血清IgE、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)水平比较,差异无统计学意义(P>0.05),具有可比性。治疗后2组上述指标水平均明显下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前2组生活质量指数(DLQI)比较,差异无统计学意义(P>0.05),具有可比性。治疗后2组DLQI均明显升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。2组在治疗期间均无明显不良反应发生。治疗结束后随访3个月,对照组复发4例,复发率为6.06%(4/66);治疗组复发2例,复发率为2.56%(2/78)。2组复发率比较,差异有统计学意义(P<0.05)。结论妇安消疹洗液、玉屏风颗粒、白及多糖乳膏三联疗法治疗儿童特应性皮炎,能明显改善患儿临床症状,提高机体免疫力和生活质量,且安全有效,复发率低,值得临床推广应用。

Objective To observe the clinical efficacy of triple therapy with Fu’an Xiaozhen Xiye(妇安消疹洗液),Yupingfeng Keli(玉屏风颗粒)and Baiji Duotang Rugao(白及多糖乳膏)for atopic dermatitis in children.Methods From January 2017 to December 2018,totally 156 cases of children with atopic dermatitis admitted into dermatosis center of Shiyan Municipal Taihe Hospital(Hospital Affiliated to Hubei University of Medicine)were chosen and divided into treatment group and control group according to random number table method,with 78 cases in each group.The control group was given oral administration of Yupingfeng Keli,with the skin lesions smeared with Baiji Duotang Rugao and zinc oxide paste.The treatment group was given oral administration of Yupingfeng Keli,with the skin lesions smeared with Baiji Duotang Rugao and embrocated with Fu’an Xiaozhen Xiye.One week constituted 1 course of treatment for both groups,and we kept statistics about the clinical efficacy after 4 consecutive courses of treatment.Results The total effective rate of the control group was 84.6%(66/78),that of the treatment group was 100.0%(78/78),and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the difference was not statistically significant in serum levels of immunoglobulin E(IgE),interleukin-4(IL-4)and IL-5 between the 2 groups(P>0.05),and they were comparable.After treatment,the above mentioned indicators levels all significantly decreased,and the difference was statistically significant compared with those of the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).Before treatment,the difference was not statistically significant in dermatology life quality index(DLQI)between the 2 groups(P>0.05),and they were comparable.After treatment,DLQI of the 2 groups all significantly increased,and the difference was statistically significant compared with those in the same group before treatment(P<0.05),moreover,the treatment group increased more significantly(P<0.05).No significant adverse reactions occurred in both groups during the treatment.A 3-month follow-up was conducted after treatment,4 cases recurred in the control group,and the recurrence rate was 6.06%(4/66);2 cases recurred in the treatment group,and the recurrence rate was 2.56%(2/78).There was statistical significant difference in recurrence rate between the 2 groups(P<0.05).Conclusion It can significantly improve the clinical symptoms,improve the body immunity and life quality to use triple therapy with Fu’an Xiaozhen Xiye,Yupingfeng Keli and Baiji Duotang Rugao for atopic dermatitis in children,having safety,efficacy and low recurrence rate,which is worthy of clinical promotion and application.