茵栀黄颗粒联合抚触、蓝光光疗治疗新生儿黄疸40例临床观察

Clinical observation on 40 cases of neonatal jaundice treated by Yinzhihuang Keli (茵栀黄颗粒)combined with stroking and blue light phototherapy

目的观察茵栀黄颗粒联合抚触、蓝光光疗治疗新生儿黄疸的临床疗效。方法选取2017年10月至2019年3月兰州市西固区人民医院新生儿科收住的新生儿黄疸患儿120例,采用随机数字表法分为蓝光光疗组(简称光疗组),茵栀黄颗粒+蓝光光疗(简称药物组),茵栀黄颗粒+抚触组+蓝光光疗(简称抚触组),各40例。光疗组采用蓝光光疗,药物组在光疗组治疗方法的基础上口服茵栀黄颗粒,抚触组在药物组治疗方法的基础上给予抚触治疗。3组均连续治疗3 d后统计临床疗效,并比较黄疸消退时间和每日排便次数,治疗前和治疗24 h、72 h后血清总胆红素(TBIL)水平变化。结果光疗组总有效率为87.5%(35/40),药物组为92.5%(37/40),抚触组为97.5%(39/40),药物组和抚触组的总有效率均显著优于光疗组(P<0.05)。治疗前,3组血清TBIL水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后3组血清TBIL水平均明显下降,与同组治疗前比较,差异有统计学意义(P<0.05),且抚触组下降更显著,与光疗组和药物组治疗72 h比较,差异均有统计学意义(P<0.05)。抚触组在黄疸消退时间和每日排便次数均明显优于光疗组和药物组,差异有统计学意义(P<0.05)。结论茵栀黄颗粒联合抚触、蓝光光疗治疗新生儿黄疸疗效显著,可促进胆红素的代谢,缩短病程,值得临床推广应用。

Objective To observe the clinical efficacy of Yinzhihuang Keli(茵栀黄颗粒) combined with stroking and blue light phototherapy in the treatment of neonatal jaundice.Methods From October 2017 to March 2019, 120 cases of neonatal jaundice admitted into and hospitalized in neonatology department of Xigu District The People’s Hospital in Lanzhou were divided into blue light phototherapy group(phototherapy group for short),Yinzhihuang Keli+blue light phototherapy group(medicinal group for short),and Yinzhihuang Keli+stroking+blue light phototherapy group(stroking group for short),with 40 cases in each group.Phototherapy group used blue light phototherapy, medicinal group was given oral administration of Yinzhihuang Keli on the basis of the therapeutic method of phototherapy group, and stroking group was given stroking on the basis of the therapeutic method of medicinal group.We kept statistics about the clinical efficacy of the 3 groups after 3 days of continuous treatment, and compared the jaundice subsidence time, daily defecation frequency, the change levels of serum total bilirubin(TBIL) before treatment, 24 hours and 72 hours after treatment.Results The total effective rate of phototherapy group was 87.5%(35/40),that of medicinal group was 92.5%(37/40), and that of stroking group was 97.5%(39/40),the total effective rate of medicinal group and stroking group were significantly superior to that of phototherapy group(P<0.05).Before treatment, there was no significant difference in TBIL levels among the 3 groups(P>0.05),and they were comparable;After treatment, TBIL levels of the 3 groups significantly decreased, and the difference was statistically significant compared with those before treatment in the same group(P<0.05),moreover, the decrease in stroking group was more significant, and the difference was statistically significant compared with phototherapy group and medicinal group after 72 hours of treatment(P<0.05).The jaundice subsidence time and daily defecation frequency of stroking group were significantly superior to those of phototherapy group and medicinal group, and the difference was statistically significant(P<0.05).Conclusion It has marked efficacy to use Yinzhihuang Keli combined with stroking and blue light phototherapy in the treatment of neonatal jaundice, which can promote bilirubin metabolism and shorten the course of disease.It deserves clinical promotion and application.