泻脾升清汤辅助治疗小儿疱疹性口腔炎风热乘脾证40例临床观察

Clinical observation on 40 cases of herpetic stomatitis in children with wind-heat attacking spleen syndrome treated by Xiepi Shengqing Tang(泻脾升清汤)as adjuvant therapy

目的观察泻脾升清汤辅助治疗小儿疱疹性口腔炎风热乘脾证的临床疗效。方法选取2019年1月至2020年1月温州市中医院口腔科收治的疱疹性口腔炎风热乘脾证患儿80例,采用随机数字表法分为对照组和治疗组,各40例。对照组予利巴韦林气雾剂外喷,口服维生素B2,局部外涂康复新液;若体温≥38.5℃时,口服布洛芬混悬液降温;合并细菌感染者,予头孢克肟颗粒口服。治疗组在对照组治疗方法的基础上予中药泻脾升清汤口服。2组均连续治疗5 d后统计疗效。结果对照组总有效率为72.5%(29/40),治疗组为92.5%(37/40),2组比较,差异有统计学意义(P<0.05)。治疗前2组发热、咽部体征、疼痛、疱疹积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述证候积分均明显下降,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组下降更显著(P<0.05)。治疗组疱疹消退时间,咽痛、流涎消失时间及体温恢复正常时间均明显短于对照组,2组比较,差异有统计学意义(P<0.05)。2组在治疗期间,均未见明显不良反应发生。结论泻脾升清汤辅助治疗小儿疱疹性口腔炎风热乘脾证,能显著改善临床症状,疗效确切,且无明显不良反应发生,值得临床推广应用。

Objective To observe the clinical efficacy of Xiepi Shengqing Tang(泻脾升清汤)in adjuvant treatment of herpetic stomatitis in children with wind-heat attacking spleen syndrome.Methods From January 2019 to January 2020,80 cases of herpetic stomatitis in children with wind-heat attacking spleen syndrome admitted into stomatology department of Wenzhou Hospital of TCM were divided into control group and treatment group according to random number table method,with 40 cases in each group.The control group was given ribavirin aerosol spray,oral administration of vitamin B2,and topical external application of Kangfuxin Ye(康复新液);When the body temperature was above 38.5℃,ibuprofen suspension was taken orally to lower the temperature;Patients concomitant with bacterial infection were given cefixime granules orally.The treatment group was given Xiepi Shengqing Tang on the basis of the therapeutic methods of the control group.We kept statistics after the 2 groups were continuously treated for 5 days.Results The total effective rate was 72.5%(29/40)in the control group and 92.5%(37/40)in the treatment group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,there was no significant difference in the scores of fever,pharyngeal signs,pain and herpes between the 2 groups(P>0.05),and they were comparable;After treatment,the above mentioned syndrome scores of the 2 groups significantly decreased,and the difference was statistically significant compared with those before treatment in the same group(P<0.01),moreover,the decrease in the treatment group was more significant(P<0.05).The subsidence time of herpes,the disappearance time of pharyngeal pain,salivation and time of body temperature returning to normal in the treatment group were significantly shorter than those in the control group,and the difference was statistically significant between the 2 groups(P<0.05).No occurrence of marked adverse reaction in the 2 groups during the treatment.Conclusion It can significantly improve the clinical symptoms with definite efficacy and no occurrence of marked adverse reaction to use Xiepi Shengqing Tang in adjuvant treatment of herpetic stomatitis in children with wind-heat attacking spleen syndrome,which deserves clinical promotion and application.