泽泻汤的研究现状

Research Status of Zexietang

泽泻汤出自《金匮要略》,该方由泽泻和白术2味中药配伍而成,具有利水除饮、健脾制水的功效。相较于西药治疗有关病证,泽泻汤不仅可以提高疗效,还能降低不良反应的发生,实现长期稳定给药。笔者通过整理泽泻汤的近些年研究情况,对其化学成分、药理作用及临床应用等方面进行整理与分析,发现泽泻汤中的主要活性成分为泽泻醇A和B,23-乙酰泽泻醇B和C,白术内酯(白术内酯Ⅰ,Ⅱ,Ⅲ)和多糖等,具有利尿、降血脂、降血压、抗炎等药理作用,可加味配伍用于高血压病、高血脂症、眩晕病、脑血管供血不足等疾病的治疗,且疗效明显。通过对近些年泽泻汤的研究概况进行总结,可进一步明确其活性成分和药理作用机制,为泽泻汤的临床应用提供依据,并为下一步的研究指引方向。

Zexietang is derived from Jingui Yaolue(《金匮要略》),which is composed of Alismatis Rhizoma and Atractylodis Macrocephalae Rhizoma,and has the effect of inducing diuresis and invigorating the spleen to produce water. Compared with western medicine in the treatment of related diseases,Zexietang can not only improve the curative effect,but also reduce the occurrence of adverse reactions,so as to achieve long-term stable administration. The authors sorted out and analyzed the chemical composition,pharmacological effect and clinical application of Zexietang in recent years. It was found that the main active components of Zexietang were alismol A and B,23-acetyl-alismol B and C,atractylenolides(atractylenolide Ⅰ,Ⅱ,Ⅲ)and polysaccharides.Pharmacological experiments showed that they had diuretic,hypolipidemic,anti-inflammatory and others. And it can be used in the treatment of hypertension,hyperlipidemia,vertigo,cerebral vascular insufficiency and other diseases combined with other Chinese materia medica,and the curative effect is obvious. By summarizing the research status of Zexietang in recent years,its active components and pharmacological mechanism can be further clarified,which provides the basis for the clinical application of Zexietang and guides the direction of its further research.