胸腺肽对肺癌根治术后患者外周血单个核细胞中Treg比例的影响

Effect of thymosin on the proportion of Tregs in peripheral blood mononuclear cells in patients undergoing radical resection for lung cancer

目的探讨胸腺肽对肺癌根治术后患者外周血单个核细胞中Treg比例的影响。方法选取2017年2月至2019年8月间西电集团医院收治的行肺癌根治术的210例患者作为研究对象,根据随机数表法把患者分为观察组与对照组,每组105例。对照组患者采用胸腔镜下肺癌根治术,观察组患者在此基础上给予胸腺肽治疗,共治疗观察2周。比较两组患者的围手术指标、术后恢复指标、血清免疫球蛋白G(IgG)、IgA及单个核细胞Treg细胞比例。结果两组患者手术时间和术中出血量比较,差异无统计学意义(P>0.05),观察组的术后拔除引流管时间、术后下床时间和术后住院时间均少于对照组,差异均有统计学意义(均P<0.05)。两组患者术后2周的血清IgG含量高于术前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组患者手术前后血清IgA含量比较,差异无统计学意义(P>0.05)。术后2周,两组患者的单个核细胞Treg细胞比例高于术前,观察组高于对照组,差异有统计学意义(P<0.05)。术后随访1年,观察组的生活质量各维度评分均低于对照组,差异有统计学意义(P<0.05)。结论胸腺肽在肺癌根治术后患者的应用能提高外周血单个核细胞中Treg比例,促进血清Ig G的释放,从而有利于患者康复并提高患者的生活质量。

Objective To investigate the effect of thymosin on the proportion of regulatory T cells(Tregs)in peripheral blood mononuclear cells in patients undergoing radical operation of lung cancer.Methods From February 2017 to August 2019,210 patients who underwent resection resection for lung cancer.Two hundred and ten pateints undergoing radical operation of lung cancer at Xian XD Group Hospital were selected from February 2017 to August 2019.They were divided into an observation group and a control group with 105 pateints in each group.Thymosin was administered to the observation group based on thoracoscopic radical resection for lung cancer and the control group only underwent thoracoscopic radical resection for lung cancer.They were observed for 2 weeks.Perioperative indexes,postoperative recovery indexes,Serum immunoglobulin G(Ig G),Ig A and proportion of Tregs in mononuclear cells were compsred between the two groups.Results There were no significant difference in the duration of operation and intraoperative blood loss between the two groups(P>0.05).The postoperative drainage tube removal time,postoperative time to out-of-bed acties and postoperative length of hospital stay were less in the observsation group than in the control group(all P<0.05).At 2 weeks after the operation,serum Ig G level was higher in the two groups than preoperatively with the observation group high than the control group(all P<0.05).There were no significant difference in serum Ig A level between the two groups before and after surgery(P>0.05).At 2 weeks after the operation,the proportion of mononuclear Treg cells increased in the two groups with the observation group higher than the control group(all P<0.05).During a followed-up of1 year,quality of life scores in different aspects were lower in the observation group than in the control group(all P<0.05).Conclusion Thymosin can increase the proportion of Treg in peripheral blood mononuclear cells and promote the release of serum Ig G,which is conducive to recovery and improves quality of life in patients undergoing radical operation of lung cancer.