摘要
报道了一种合成抗帕金森药甲磺酸沙芬酰胺的新工艺。它是以对羟基苯甲醛和间氟氯苯为起始物料,经醚化、还原、卤代、缩合和成盐制得甲磺酸沙芬酰胺,总收率为58.2%,纯度达99.5%。该新工艺操作简便,产品纯度高,适合工业化生产。
A new synthetic process of safinamide mesilate,an anti-parkinson drug was reported.Using 3-fluorobenzyl chloride and p-hydroxybenzaldehyde as the starting material,safinamide mesylate was synthesized through five steps,including etherification,reduction,halogenation,substitution and salification with a total yield of 58.2%and a purity of 99.5%.This process has some advantages such as convenient operations,high purity and suitable for industrial production.
作者
王进家
刘飞
章泽洲
柴雨柱
徐丹
朱春霞
WANG Jin-jia;LIU Fei;ZHANG Ze-zhou;CHAI Yu-zhu;XU Dan;ZHU Chun-xia(Nanjing Chia Tai-Tianqing Pharmaceutical Co.,Ltd.,Nanjing 210046,China)
出处
《精细与专用化学品》
CAS
2021年第7期43-45,共3页
Fine and Specialty Chemicals