侧流分析装置的结构改进和化学改性研究进展

Recent advances in structural improvements and chemical modifications of lateral flow assay devices

侧流分析(lateral flow assay,LFA)是一种重要的纸基快速检测技术,具有操作简便、成本低廉等特点,但存在灵敏度低和信号弱等问题.近年来,对LFA的技术改进与性能改善已成为即时检测领域急需解决的问题.本文综述了利用结构改进、化学改性以及其他辅助手段改善LFA灵敏度的研究工作,分析了相关方法的原理和检测性能,剖析了各种改进手段存在的优缺点,并对LFA技术发展前景进行了展望.

Lateral flow assay(LFA)is an important paper-based technique amenable for rapid and point-of-care testing.It features as low cost and simple operations.However,a main challenge often comes from weak detection signals and low sensitivity.Here we summarize the advances in new research aiming at improving the sensitivity of LFA through structural improvements,chemical modifications,and other auxiliary methods.We discuss the principle and operation,performance,unique features,advantages and remaining issues of each improvement strategy.We highlight current challenges and provide perspectives on future research directions with respect to developing new strategies for improving LFA.