重性抑郁症基于低频振幅的静息态功能磁共振成像结果观察

Observation on resting-state functional magnetic resonance imaging results of major depressive disorder based on the amplitude of low-frequency fluctuations

目的探讨重性抑郁症(MDD)基于低频振幅(ALFF)的静息态功能磁共振成像(fMRI)结果。方法前瞻性选取2017年1月至2019年1月在本院心理门诊就诊的重性抑郁症患者35例作为MDD组,选择同期在本院进行体检的健康志愿者35例作为对照组。比较两组fMRI不同脑区mALFF值(ALFF值M化处理获得)的不同。结果MDD组患者右侧前额叶皮质、右侧颞上回、右侧颞下回、左侧岛叶、左侧额内侧回、左侧直回的mALFF值较对照组明显升高,差异均有统计学意义(P<0.05)。MDD组患者双侧补充运动区、右侧舌回、左侧楔前叶、左侧舌回的mALFF值较对照组明显减低,差异均有统计学意义(P<0.05)。结论 MDD患者静息态下右侧前额叶皮质、右侧颞上回、右侧颞下回、左侧岛叶、左侧额内侧回、左侧直回的mALFF值增加,双侧补充运动区、双侧舌回、左侧楔前叶m ALFF值降低,这些脑区神经功能损害可能为引发MDD的基础。

Objective To explore the results of resting functional magnetic resonance imaging(fMRI)of major depressive disorder(MDD)based on the amplitude of low-frequency fluctuations(ALFF).Methods A total of 35 patients with MDD who visited our psychological clinic from January 2017 to January 2019 were prospectively selected as the MDD group.35 healthy volunteers who had physical examination in our hospital in the same period were selected as the control group.mALFF values(obtained by the M processing of ALFF value)of different brain regions in fMRI were compared between the two groups.Results mALFF values of right prefrontal cortex,right superior temporal gyrus,right inferior temporal gyrus,left insula,left medial frontal gyrus and left direct gyrus in MDD group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).mALFF values of bilateral supplementary motor areas,right lingual gyrus,left anterior cuneiform lobe and left lingual gyrus in MDD group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion mALFF values of right prefrontal cortex,right superior temporal gyrus,right inferior temporal gyrus,left insular lobe,left medial frontal gyrus and left direct gyrus increase,while mALFF values of bilateral supplementary motor areas,bilateral lingual gyrus and left anterior cuneiform lobe decrease in MDD patients at rest,which may lead to the basis of MDD.