摘要
The current blockage during DNA molecule translocation through a solid-state nanopore is very important in DNA analysis techniques based on nanopores.We use Poisson-Nernst-Planck descriptions of electrolyte behavior in a nanopore with and without the presence of DNA molecules to simulate the nanopore conductance and current blockage of DNA molecules. Actual experimental parameters,such as pore size,length of nanopores,DNA drift velocity,and the charge issue of nanopores and DNA,are applied to evaluate the precise current blockage amplitude,which is found to agree very well with the experimental results.
作者
鲁铂
金伟良
赵清
俞大鹏
LU Bo;JIN Wei-Liang;ZHAO Qing;YU Da-Peng(State Key Laboratory for Mesoscopic Physics and Electron Microscopy Laboratory,School of Physics,Peking University,Beijing 100871)
基金
Supported by the National Natural Science Foundation of China under Grant Nos 50902004 and 11023003
the National Basic Research Program of China under Grant Nos 2009CB623703 and 2011CB707601
the International Science&Technology Cooperation Program of China Sino Swiss Science and Technology Cooperation Program(2010DFA01810).
