摘要
The capability of a biological neuron to discriminate the intensity of external stimulus is measured in its dynamic range.In previous studies,a few factors have been reported to be able to enhance the dynamic range,e.g.,electrical coupling and active dendrites.Here we numerically show that intrinsic channel noise within neurons has a subtle effect in neuronal dynamic range modulation.Our simulation results indicate that for relatively weak noise intensity,the dynamic range of the neuron is enhanced significantly.However,as the noise intensity becomes stronger,the dynamic range of the neuron is weakened.Further investigation suggests that sodium channel noise and potassium channel noise play opposite roles in modulating the dynamic range.Consequently,the model results suggest a new function of channel noise,that is,a proper value of noise intensity could optimize the dynamic range of neurons.
作者
汪雷
张溥明
梁培基
邱意弘
WANG Lei;ZHANG Pu-Ming;LIANG Pei-Ji;QIU Yi-Hong(School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240)
基金
Supported by the National Natural Science Foundation of China under Grant No 61075108
the Natural Science Foundation of Shanghai under Grant No 12ZR1413800.