基于数据挖掘的中医药治疗糖尿病下肢血管病变用药规律

Study on the medication regularity of Traditional Chinese Medicine on treating diabetic lower extremity arterial disease based on data mining

目的利用数据挖掘技术分析中医药治疗糖尿病下肢血管病变的用药规律。方法检索中国学术期刊数据库(万方数据)、中国知识资源总库(CNKI)、中国生物医学文献服务系统(SinoMed)、中文科技期刊数据库(重庆维普)2000年1月-2020年4月有关中医药治疗糖尿病下肢血管病变的临床研究文献并建立数据库,采用Excel 2019、SPSS 25、SPSS Modeler 18对药物进行频率分析、聚类分析和关联分析。结果纳入文献175篇,包括201个处方、186种中药。使用频率较高的前5味中药分别为黄芪、当归、川芎、牛膝、红花;性味归经以性温为主,味甘为首,肝、心经为多;活血化瘀药使用频率最高,补气药、补血药次之;关联规则分析提示黄芪、当归、川芎为最常见的药物组合。结论糖尿病下肢血管病变治疗以活血化瘀、补益气血为主,辨证兼施祛风散寒、温阳通络、化痰除湿、养阴清热之法。黄芪、当归、川芎为核心用药,可联用牛膝、地龙、赤芍、丹参、桃仁、红花提升疗效。

Objective To explore the medication regularity of Traditional Chinese Medicine(TCM)for diabetic lower extremity arterial disease(DLEAD)based on data mining.Methods Search for the clinical literature of treating DLEAD in recent 20 years from China Academic Journal Database(Wanfang Data),China National Knowledge Resources Database(CNKI),China Biomedical Literature Service System(SinoMed)and Chinese Science and Technology Journal Database(Chongqing VIP)dated.The frequency analysis,cluster analysis and association analysis for TCM were carried out respectively through Excel 2019,SPSS 25 and SPSS Modeler 18.Results There are altogher 175 papers mentioning 201 prescriptions and 186 herbs,among which the top 5 herbs that are used frequently are Astragali Radix,Angelicae Sinensis Radix,Chuanxiong Rhizoma,Achyranthis Bidentatae Radix,Carthami Flos.The taste are mainly sweet and the nature is warm,with liver meridian as the most important maridian.The herbs for activating blood circulation and removing blood stasis are frequently used,followed by Qi tonic and blood tonic herbs.Association Rule Analysis suggested that Astragali Radix,Angelicae Sinensis Radix,Chuanxiong Rhizoma are the herbs that are frequently combined together.Conclusions The medication for treating DLEAD mainly focuses on promoting blood circulation and removing blood stasis and tonifing Qi and blood.At the same time,the treatment should focus on dispelling wind and dispersing cold,warming yang and unblocking collaterals,resolving phlegm and removing dampness,nourishing yin and clearing heat based on different syndromes.Astragali Radix,Angelicae Sinensis Radix,Chuanxiong Rhizoma were the core herbs.It can be combined with Achyranthis Bidentatae Radix,Pheretma,Paeoniae Radix Rubra,Salviae miltiorrhizae Radix et Rhizoma,Peach Kernel,Carthami Flos to improve the curative effect.