苍附苁仙汤辅助治疗多囊卵巢综合征不孕症痰湿阻滞证42例临床观察

Clinical observation on 42 cases of infertility due to polycystic ovary syndrome with phlegm-dampness obstructing syndrome treated by Cangfu Congxian Tang( 苍附苁仙汤) as adjuvant therapy

目的观察苍附苁仙汤辅助治疗多囊卵巢综合征(PCOS)不孕症痰湿阻滞证的临床疗效。方法将84例PCOS不孕症痰湿阻滞证患者采用随机数字表法分为治疗组和对照组,各42例。对照组采用常规西医治疗,治疗组在对照组治疗方法的基础上联合苍附苁仙汤治疗。2组均治疗3个月经周期。比较2组排卵率、妊娠率以及治疗前后卵泡平均直径、性激素[促黄体生成素(LH)、促卵泡生成激素(FSH)]水平。结果治疗组排卵率和妊娠率分别为85.71%(36/42)、50.00%(21/42),对照组分别为61.90%(26/42)、26.19%(11/42),2组比较差异均有统计学意义(P <0.05)。治疗3个月经周期后2组卵泡平均直径均明显增大,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组增大更明显,与对照组治疗后比较差异有统计学意义(P<0.05)。治疗3个月经周期后2组LH水平及LH/FSH均明显降低,FSH水平均明显升高,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组对各项指标的改善作用更明显,与对照组治疗后比较差异均有统计学意义(P<0.05)。结论苍附苁仙汤联合常规西医治疗可有效提高PCOS不孕症痰湿阻滞证患者的卵泡质量,降低LH/FSH,从而提高排卵率及妊娠率。

Objective To observe the clinical efficacy of Cangfu Congxian Tang( 苍附苁仙汤) in adjuvant treatment of infertility due to polycystic ovary syndrome( PCOS) with phlegm-dampness obstructing syndrome.Methods Eighty-four cases of infertility due to PCOS with phlegm-dampness obstructing syndrome were divided into treatment group and control group by random number table method,with 42 cases in each group. The control group was given routine Western medicine treatment,on this basis,the treatment group was combined with Cangfu Congxian Tang. Both groups were treated for 3 menstrual cycles. Ovulation rate,pregnancy rate,average diameter of follicle and sex hormone [luteinizing hormone( LH),follicular stimulating hormone( FSH) ]levels before and after treatment were compared between the two groups. Results The ovulation rate and pregnancy rate of the treatment group were 85.71%( 36/42) and 50.00%( 21/42),respectively;and those of the control group were 61.90%( 26/42) and 26.19%( 11/42),respectively,there were significant differences between the 2 groups( P<0.05).After 3 menstrual cycles of treatment,the average diameter of follicles in the 2 groups increased significantly,and the difference was statistically significant compared with that in the same group before treatment( P<0.05),moreover,the increase in the treatment group was more significant than that in the control group after treatment( P <0.05). After 3 menstrual cycles of treatment,the LH levels and LH/FSH in the 2 groups significantly decreased,and the levels of FSH significantly increased,and the difference was statistically significant compared with those before treatment in the same group( P<0.05),moreover,and the improvement effect on each index in the treatment group was more significant,and the difference was statistically significant compared with those in the control group after treatment( P<0.05).Conclusion Cangfu Congxian Tang combined with routine Western medicine treatment can effectively improve the quality of follicles and decrease LH/FSH level of infertility due to PCOS with phlegmdampness obstructing syndrome,thereby improving the ovulation rate and pregnancy rate.