抗菌光动力疗法在种植体周围疾病中的应用

Clinical application of antimicrobial photodynamic therapy in the treatment of peri-implant diseases

抗菌光动力疗法(antimicrobial photodynamic therapy,aPDT)的基本原理是通过特定波长的可见光与光敏剂相互作用,产生单线态氧等细胞毒性物质,以杀死目标细菌/细胞。在种植体周围疾病的治疗中,因单纯使用机械清创术存在一定局限性,aPDT作为一种新型辅助疗法在临床上逐渐展开应用。尽管单个研究表明,aPDT可在短期内改善种植体周围疾病的临床指标,尤其是在吸烟及糖尿病患者中展现出潜在的应用前景;但高等级证据资料(指南共识、系统评价等)并未推荐将其作为种植体周围疾病的常规疗法。未来的研究方向应专注于规范aPDT的操作流程,从而建立高质量的临床研究证据以验证其长期疗效。

The basic principle of antimicrobial photodynamic therapy(aPDT)is to produce singlet oxygen and other cytotoxic substance through the interaction of visible light of a specific wavelength with the photosensitizer,to kill the targeted bacteria/cell.Because of the limitations of mechanical debridement,aPDT has been applied clinically as a novel adjunctive therapy.Although existing single studies demonstrated improvement of peri-implant parameters in a short term,and has shown potential application prospects,especially in smoking and diabetes patients;high-level evidence(guideline consensus,systematic reviews,etc.)did not recommend aPDT as a routine therapy for peri-implant diseases.Future research should focus on standardizing the procedures of aPDT in order to establish high-quality clinical evidence to verify its long-term efficacy.