基于数据挖掘舒琦瑾辨治胃癌用药规律

Administration Rule of SHU Qijin in Treating Gastric Cancer According to Syndrome Differentiation Based on Data Mining

目的:总结舒琦瑾辨治原发性胃癌用药规律。方法:纳入舒琦瑾门诊原发性胃癌患者66例,共919诊次,采用Microsoft Office Excel 2003软件建立方剂数据库,对药物频数、类别、性味进行描述性分析,运用IBM SPSS19.0和IBM SPSSmodeler 18.0软件对频数最高的45味药物进行系统聚类和相关性分析。结果:66例患者919诊次使用中药167味,累计用药频数13553次,频数最高者为藤梨根,其次为无花果、薏苡仁;类别频数最高者为补虚药,其次为清热药、利水渗湿药、活血化瘀药;性味以甘、辛、苦、平为主;聚类分析将药物分为7类,涉及参苓白术散、生脉散、三仁汤等,药对诃子和淫羊藿、白术和紫苏梗等;关联规则分析得出药组:藤梨根和无花果、黄芪和党参等。结论:舒琦瑾从气、血、水、湿、寒、热切入辨治胃癌,主以养阴益气、清热利湿治之,兼顾活血消癥、理气化痰,气血同治,用药善以甘、辛、苦、平配伍。

Objective:To summarize the administration rule of SHU Qijin in treating primary gastric cancer according to syndrome differentiation.Methods:Sixty-six patients with primary gastric cancer in outpatient department of SHU Qijin were included,with a total of 919 consultations.A prescription database was established via Microsoft Office Excel 2003 to descriptively analyze the frequency,category,nature and flavor of the Chinese herbs.IBM SPSS 19.0 and IBM SPSS Modeler 18.0 were used for systematic clustering and correlation analysis of the 45 herbs with the highest frequency.Results:A total of 167 kinds of Chinese herbs were used in the 919 visits of the 66 patients,and the cumulative frequency of use was 13553 times.The herb of highest frequency was Chinese actinidia root,followed by ficus carica and coix seed.The category with the highest frequency was herbs for tonifying deficiency,followed by herbs for clearing heat,herbs for promoting urination and percolating dampness,and herbs for invigorating blood and dissolving stasis.The nature and flavor were mainly sweet,spicy,bitter and neutral.Cluster analysis divided the herbs into seven categories,including Shenling Baizhu powder,Shengmai powder,Sanren tang,etc.,and the herb combinations were Fructus Chebulae and Herba Epimedii,Rhizoma Atractylodis Macrocephalae and Caulis Perillae,etc.According to analysis of association rule,the herb combinations were obtained as follows:Chinese actinidia root and ficus carica,Radix Astragali and Radix Codonopsis,etc.Conclusion:SHU Qijin focuses on the differentiation and treatment of gastric cancer from qi,blood,water,dampness,coldness and heat,and he mainly treats it by nourishing yin and tonifying qi,clearing heat and dissolving dampness,giving consideration to invigorating blood and eliminating concretions,regulating qi and dissolving phlegm,and combining qi and blood.He is good at prescribing formula involving herbs of sweet,acrid,bitter and neutral.