浓缩生长因子在种植与牙周领域应用的研究及进展

Application and research progress of concentrated growth factor in oral implantology and periodontology

引导组织再生术(guided tissue regeneration,GTR)与引导骨再生术(guided bone regeneration,GBR)是修复、重建口腔软硬组织缺损的常规术式之一。面对美学与功能的双重挑战,GTR与GBR经过近数十年的临床应用,带动了无数骨移植、软组织移植替代材料的发展。然而,现有的材料仍存在诸多的应用限制:异体移植材料存在交叉感染、免疫排斥等风险,屏障膜的可降解性和机械强度往往难以兼得。近年来,新型移植材料自体浓缩血小板制品因制备便捷、生物安全性和软硬组织修复能力良好,已在口腔临床领域获得了广泛的应用。其中,新一代的浓缩生长因子(concentrated growth factors,CGF)具有相较前代更为牢固的纤维蛋白支架,内部储存更为丰富的生长因子、细胞因子及功能细胞,具有优秀的诱导细胞增殖分化、促胞外基质合成及血管再生等能力。本文重点就浓缩生长因子在口腔软硬组织增量方面的特点及研究进展做一综述。

Guided tissue regeneration(GTR)and guided bone regeneration(GBR)are the most comm on surgical procedures for soft and hard tissue regeneration in the field of dentistry.After decades of clinical applications of these techniques,challenges of esthetics and function rehabilitation have triggered the development of numerous bone or soft tissue subsitutes.However,the existing allograft or xenograft materials still carry potential risks of cross-infection and immune rejection,and for barrier membranes,acceptable mechanical strength and biodegradation may not be both achieved in most cases.These years,autologous platelet concentrates have emerged as innovative graft materials and come into common use due to the easiness of preparation,excellent biocompatibility and regenerative properties.Concentrated growth factor(CGF)is a new generation of platelet concentrates.The fibrin matrix scaffold in side is much stiffer than its previous generations,while the richer growth factors,cytokines and cells it contains better promote cell proliferation and differentiation.extracellular matrix synthesis and angiogenesis.This article reviewed the characteristics of CGF in terms of bone and soft tissue augmentation in oral cavity and its related research progress in dental clinics.