盆腔器官脱垂患者阴道组织原纤维蛋白-1和纤维蛋白-5的表达及意义

Expressions and significance of fibrillin-1 and fibrin-5 in vaginal tissue of patients with pelvic organ prolapse

目的探讨盆腔器官脱垂患者阴道组织原纤维蛋白-1(Fibrillin-1)和纤维蛋白-5(Fibulin-5)的表达情况,并分析其临床意义。方法选取2018年2月-2019年10月诸暨市人民医院收治的盆腔器官脱垂患者90例为观察组,其中Ⅱ期患者51例,Ⅲ期患者39例;另选取同期该院收治的因子宫肌瘤行子宫全切术的患者80例为对照组。采用免疫组化染色法检测阴道组织Fibrillin-1和Fibulin-5表达情况。结果观察组患者阴道组织Fibrillin-1和Fibulin-5阳性表达率明显低于对照组,差异均有统计学意义(均P<0.05)。观察组POP-Q分期Ⅲ期患者阴道组织Fibrillin-1和Fibulin-5阳性表达率明显低于Ⅱ期患者,差异均有统计学意义(均P<0.05)。观察组患者阴道组织中Fibrillin-1与Fibulin-5表达呈正相关关系(P<0.05)。结论盆腔器官脱垂患者阴道组织Fibrillin-1和Fibulin-5表达降低,随脱垂程度加重,表达明显降低,两者间存在相关性。

Objective To explore the expressions of fibrillin-1 and fibrin-5 in vaginal tissue of patients with pelvic organ prolapse, analyze the clinical significance. Methods From February 2018 to October 2019, 90 patients with pelvic organ prolapse treated in Zhuji People’s Hospital were selected as observation group, including 51 patients of stage Ⅱ and 39 patients of stage Ⅲ;80 patients undergoing total hysterectomy due to uterine fibroids were selected as control group. Immunohistochemical staining was used to detect the expressions of fibrillin-1 and fibrin-5 in vaginal tissue. Results The positive expression rates of fibrillin-1 and fibrin-5 in vaginal tissue in observation group were statistically significantly lower than those in control group(P<0.05). In observation group, the positive expression rates of fibrillin-1 and fibrin-5 in vaginal tissue of patients of stage Ⅲ were statistically significantly lower than those in vaginal tissue of patients of stage Ⅱ(P<0.05). In observation group, fibrillin-1 expression was positively correlated with fibrin-5 expression(P<0.05). Conclusion The expressions of fibrillin-1 and fibrin-5 in vaginal tissue in patients with pelvic organ prolapse decrease, which decrease with increase of degree of pelvic organ prolapse, there are significant correlations.