帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍的效果观察

Effect observation of Paroxetine combined with Olanzapine in the treatment of depression complicated with sleep disorder

目的探讨帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍的临床效果。方法选取辽宁省人民医院2018年6月—2020年10月收治的180例抑郁症并发睡眠障碍患者作为研究对象,统一编号后按照单双数法分为常规组(n=90)和实验组(n=90)。常规组采用帕罗西汀片单独治疗方法,实验组采用帕罗西汀联合奥氮平治疗方法。比较两组的临床疗效、睡眠质量、抑郁情况及睡眠情况。结果实验组治疗后的总有效率(94.44%)低于常规组(83.33%),差异有统计学意义(P<0.05)。两组治疗前的睡眠质量、抑郁情况比较,差异无统计学意义(P>0.05);治疗后实验组的汉密顿抑郁量表(HAMD)、匹兹堡睡眠质量指数评分低于常规组,睡眠总时间长于常规组,睡眠潜伏期、觉醒时间短于常规组,觉醒次数少于常规组,差异有统计学意义(P<0.05)。结论应用帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍对患者的抑郁情况、睡眠质量、睡眠情况均有明显改善作用,同时还可以提高患者的临床总有效率,值得推广应用。

Objective To explore the clinical effect of Paroxetine combined with Olanzapine in the treatment of depression complicated with sleep disorder.Methods A total of 180 patients with depression complicated with sleep disorder admitted to People′s Hospital of Liaoning Province from June 2018 to October 2020 were selected as the study subjects.After being uniformly numbered,they were divided into the conventional group(n=90)and the experimental group(n=90)according to the method of single and double numbers.The conventional group was treated with Paroxetine Tablets alone,while the experimental group was treated with Paroxetine combined with Olanzapine.The clinical efficacy,sleep quality,depression and sleep were compared between the two groups.Results The total effective rate of the experimental group after treatment was 94.44%,which was lower than 83.33%of the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the sleep quality and depression between the two groups before treatment(P>0.05).After treatment,the scores of Hamilton depression scale(HAMD)and Pittsburgh sleep quality index(PSQI)in the experimental group were lower than those in the conventional group,the total sleep time in the experimental group was longer than that in the conventional group,the sleep latency,awakening time in the experimental group were shorter than those in the conventional group,awakening times in the experimental group was less than that in the conventional group,and the differences were statistically significant(P<0.05).Conclusion The application of Paroxetine combined with Olanzapine in the treatment of depression complicated with sleep disorder can significantly improve the depression,sleep quality and sleep condition of patients,and also can improve the clinical total effective rate of patients,which is worthy of promotion and application.