阿司匹林与小剂量阿加曲班治疗急性脑梗死的效果比较

Comparision effect between Aspirin and low-dose Argatroban in the treatment of acute cerebral infarction

目的比较阿司匹林与小剂量阿加曲班治疗急性脑梗死的效果。方法选取2017年1月—2019年12月华润辽健集团铁煤总医院收治的90例急性脑梗死患者作为研究对象,采用随机数字表法分为甲组与乙组,每组45例。在基础治疗的基础上,甲组采用小剂量阿加曲班治疗,乙组采用阿司匹林治疗,两组治疗疗程均为7 d。比较两组的临床疗效、治疗前后美国国立卫生院卒中量表(NIHSS)评分及Bathel指数评分、不良反应发生情况。结果两组治疗后的NIHSS评分均低于治疗前,Bathel指数高于治疗前,差异有统计学意义(P<0.05);甲组治疗后的NIHSS评分低于乙组,Bathel指数高于乙组,异有统计学意义(P<0.05);甲组的总有效率高于乙组,差异有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论与阿司匹林相比,小剂量阿加曲班治疗急性脑梗死的效果更佳,对于改善患者神经功能、提升生活自主能力具有显著效果,适合推广。

Objective To compare the effect between Aspirin and low-dose Argatroban in the treatment of acute cerebral infarction.Methods From January 2017 to December 2019,90 patients with acute cerebral infarction admitted to the Iron Coal General Hospital of China Resources Liaojian Group were selected as the research objects.They were divided into group A and group B according to random number table method,with 45 cases in each group.On the basis of basic treatment,group A was treated with low-dose Argatroban,and group B was treated with Aspirin.The treatment course of both groups was 7 days.The clinical efficacy,the National Institutes of Health stroke scale(NIHSS)score and Barthel index score before and after treatment,the incidence of adverse reactions were compared between the two groups.Results The NIHSS scores of the two groups after treatment were lower than those before treatment,and the Bathel index of the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05).The NIHSS score of group A after treatment was lower than that of group B,and the Bathel index of group A after treatment was higher than that of group B,the differences were statistically significant(P<0.05).The total effective rate of group A was higher than that of group B,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with Aspirin,low-dose Argatroban has better curative effect in the treatment of acute cerebral infarction,which has significant effect on improving the neurological function of patients and enhancing the ability of life autonomy,and is suitable for promotion.