泮妥拉唑联合阿莫西林治疗幽门螺杆菌感染引起的消化不良的临床效果

Clinical effect of Pantoprazole combined with Amoxicillin in treatment of dyspepsia caused by Helicobacter pylori infection

目的探讨泮妥拉唑联合阿莫西林治疗幽门螺杆菌感染引起的消化不良的临床效果。方法选取2019年8月—2020年8月解放军联勤保障部队第九八八医院第三派驻门诊部接诊的136例由于幽门螺杆菌感染引起消化不良患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各68例。对照组患者给予单一药物泮托拉唑治疗,观察组患者使用泮托拉唑联合阿莫西林治疗。比较两组患者的治疗总有效率、治疗后的各项症状(上腹痛、腹胀、嗳气、返酸)积分、不良反应总发生率。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05),观察组治疗后各项症状(上腹痛、腹胀、嗳气、返酸)积分低于对照组,差异有统计学意义(P<0.05),同时观察组的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论阿莫西林具有较强的杀菌作用,联合泮妥拉唑治疗幽门螺杆菌感染引起的消化不良,能够起到较好的治疗效果,改善患者的生活质量,同时不良反应发生率也较低,值得临床推广应用。

Objective To investigate the clinical effect of Pantoprazole combined with Amoxicillin in treatment of dyspepsia caused by Helicobacter pylori infection.Methods A total of 136 patients with dyspepsis caused by Helicobacter pylori infection who were sent to the Third Stationed Outpatient Department of the 988th in Hospital of the People′s Liberation Army Joint Logistics Support Force from August 2019 to August 2020 were selected as the research subjects.They were divided into control group and observation group by random number table method,with 68 cases in each group.Control group was treated with single drug Pantoprazole,and observation group was treated with Pantoprazole combined with Amoxicillin.The total effective rate,scores of symptoms(epigastric pain,abdominal distention,belching,acid regurgitating)after treatment and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The scores of various symptoms(upper abdominal pain,abdominal distension,belching,and acid return)in the observation group after treatment were lower than those in the control group,with statistically significant differences(P<0.05).The total incidence of adverse events in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Amoxicillin has a strong bactericidal effect,Amoxicillin combined with Pantoprazole has a better therapeutic effect and improves the quality of life of patients in the treatment of dyspepsia caused by Helicobacter pylori infecLion.The incidence of adverse evenLs is also low.Il is worLhy of clinical promoLion and applicaLion.