利奈唑胺联合环丝氨酸治疗耐多药肺结核患者的临床效果

Clinical effect of Linezolid combined with Cycloserine in the treatment of patients with multi-drug resistant pulmonary tuberculosis

目的观察利奈唑胺联合环丝氨酸治疗耐多药肺结核(MDR-PTB)患者的临床效果。方法选取2017年3月—2019年12月荆州市胸科医院住院或门诊治疗的84例MDR-PTB患者作为研究对象,根据随机数字表法将其分为两组,每组各42例。两组患者均实施基础治疗,对照组患者在基础治疗措施上加用环丝氨酸,观察组在对照组基础上加用利奈唑胺。比较两组患者的治疗总有效率、临床症状改善时间及用药期间药物不良反应发生情况。结果观察组患者的治疗总有效率(88.10%)高于对照组(66.67%),差异有统计学意义(P<0.05);观察组患者的病灶体积缩小时间、痰培养转阴时间、抗酸染色涂片转阴时间、空洞闭合时间均短于对照组,差异有统计学意义(P<0.05);两组患者治疗期间的药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论利奈唑胺联合环丝氨酸治疗MDR-PTB患者的效果显著,可尽快改善患者的临床症状,且不会增加药物不良反应发生率。

Objective To observe the clinical effect of Linezolid combined with Cycloserine in the treatment of patients with multi-drug resistant pulmonary tuberculosis(MDR-PTB).Methods Eighty-four MDR-PTB patients who were hospitalized or outpatient in Jingzhou Chest Hospital from March 2017 to December 2019 were selected as the research subjects.According to random number table method,the patients were divided into two groups,with 42 cases in each group.Patients in both groups received basic treatment.Patients in the control group were additionally treated with Cycloserine,and patients in the observation group were additionally treated with Linezolid.The total effective rate,improvement time of clinical symptoms and the occurrence of adverse drug reactions were compared between the two groups.Results The total effective rate of observation group(88.10%)was higher than that of control group(66.67%),and the difference was statistically significant(P<0.05).The reduction time of focus volume,the time of sputum culture turning negative,the time of acid-fast staining smear turning negative and the time of cavity closing in the observation group were all shorter than those in the control group,with statistically significant differences(P<0.05).There was no statistical significance in the total incidence of adverse drug reactions between the two groups during treatment(P>0.05).Conclusion The treatment of Linezolid combined with Cycloserine for MDR-PTB patients has a significant effect.It can improve clinical symptoms,and it will not increase the incidence of adverse drug reactions.