抗生素专项处方点评的标准制定与结果分析及临床改进措施的探析

Analysis of Standard Establishment and Results Analysis of Antibiotic Special Prescription Evaluation and Clinical Improvement Measures

目的分析抗生素专项处方点评的标准制定与结果分析及临床改进措施的意义。方法选取该院2018年1—12月开具的900张处方(对照组,没有接受任何干预),选取2019年1—12月开具的900张处方(观察组,接受抗生素专项处方点评以及改进)。将两组的抗生素处方点评情况、专项处方点评结果进行对比。结果经分析,观察组处方合理率明显高于对照组,差异有统计学意义(P<0.05);观察组的处方平均抗菌药物使用金额明显低于对照组,差异有统计学意义(P<0.05)。两组的无抗生素指征、剂型选择不合理、用法、用量不合理、联合用药不当、配伍禁忌、用药疗程过长、不良反应不明确发生率相比,差异有统计学意义(P<0.05)。经分析,1800张处方中,不合理处方为161张(8.94%),其中替硝唑片占比最高(29.81%),其次为甲磺酸左氧氟沙星片(18.63%)、左氧氟沙星片(12.42%)、头孢地尼胶囊(11.80%)等。结论抗生素专项处方点评以及改进措施的应用较大程度地提高了抗生素的合理利用率,也提高了该院处方总体质量。

Objective To analyze the standard formulation and result analysis of the evaluation of antibiotic prescriptions and the significance of clinical improvement measures.Methods Selected 900 prescriptions issued in the hospital from January to December 2018(control group,no intervention),and 900 prescriptions issued from January to December 2019(observation group,receiving antibiotics prescription reviews and improvements).The reviews of antibiotic prescriptions and the results of special prescriptions of the two groups were compared.Results After analysis,the reasonable rate of prescriptions in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05);the average amount of antibiotics prescribed in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The two groups had differences in the incidence of no antibiotic indications,unreasonable choice of dosage form,unreasonable usage and dosage,improper combination medication,contraindications,long course of medication,and unclear incidence of adverse reactions,the difference was statistically significant(P<0.05).After analysis,out of 1800 prescriptions,161 unreasonable prescriptions(8.94%),of which tinidazole tablets accounted for the highest proportion(29.81%),followed by levofloxacin mesylate tablets(18.63%),levofloxacin tablets(12.42%),cefdinir capsules(11.80%)and so on.Conclusion Comments on specific antibiotic prescriptions and the application of improvement measures have greatly improved the reasonable utilization of antibiotics and also improved the overall quality of prescriptions in the hospital.