无创呼吸机和行气利水方治疗成人轻度阻塞性睡眠呼吸暂停的临床研究

Clinical Study on Non-invasive Ventilator and Xingqi Lishui Recipe in Treating Adults with Mild Obstructive Sleep Apnea

目的研究无创呼吸机和行气利水方治疗成人轻度阻塞性睡眠呼吸暂停的临床效果。方法选取2019年4月~2020年4月我院诊治的56例成人轻度阻塞性睡眠呼吸暂停患者为研究对象,采用随机数字表法分为对照组和观察组,各28例。对照组采用无创呼吸机治疗,观察组在对照组基础上给予行气利水方治疗,比较两组临床治疗总有效率、中医证候评分、呼吸参数、血压、嗜睡评分、并发症发生情况以及复发率。结果观察组临床治疗总有效率为92.85%,高于对照组的82.14%,差异无统计学意义(P>0.05);观察组睡则打鼾、自觉胸闷、失眠多梦、形体肥胖、苔厚腻证候评分均低于对照组,差异有统计学意义(P<0.05);观察组LAD、AHI、收缩压、舒张压均低于对照组,LSaO_(2)均高于对照组,差异有统计学意义(P<0.05);两组治疗后嗜睡评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为7.14%,低于对照组的17.85%,但差异无统计学意义(P>0.05);观察组复发率为10.71%,低于对照组的25.00%,但差异无统计学意义(P>0.05)。结论无创呼吸机和行气利水方治疗成人轻度阻塞性睡眠呼吸暂停效果确切,可有效减轻患者临床中医证候,减少呼吸暂停次数、呼吸暂停时间,提高最低血氧饱和度,降低血压和嗜睡评分,且可预防并发症的发生,具有良好的临床应用有效性。

Objective To study the clinical effects of non-invasive ventilator and Xingqi Lishui Recipe in the treatment of mild obstructive sleep apnea in adults.Methods 56 adult patients with mild obstructive sleep apnea diagnosed and treated in our hospital from April 2019 to April 2020 were selected as the research objects.They were divided into the control group and the observation group by random number table method,with 28 cases in each group.The control group was treated with a non-invasive ventilator,and the observation group was treated with Xingqi Lishui Recipe on the basis of the control group.The total effective rate of clinical treatment,TCM syndrome score,respiratory parameters,blood pressure,sleepiness score,complications and recurrence rate were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 92.85%,which was higher than 82.14%in the control group,the difference was not statistically significant(P>0.05);The scores of snoring during sleep,conscious chest tightness,insomnia and dreaminess,body obesity,and thick and greasy fur in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);LAD,AHI,systolic blood pressure and diastolic blood pressure of the observation group were lower than those of the control group,and LSaO_(2) was higher than that of the control group,the difference was statistically significant(P<0.05);The sleepiness scores of the two groups after treatment were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);The complication rate in the observation group was 7.14%,which was lower than that in the control group,which was 17.85%,the difference was not statistically significant(P>0.05);The recurrence rate of the observation group was 10.71%,which was lower than 25.00%of the control group,the difference was not statistically significant(P>0.05).Conclusion Non-invasive ventilator and Xingqi Lishui Recipe are effective in treating mild obstructive sleep apnea in adults.It can effectively alleviate the clinical symptoms of traditional Chinese medicine,reduce the number of apneas,the duration of apneas,increase the minimum blood oxygen saturation,reduce blood pressure and sleepiness scores,and can prevent the occurrence of complications,and has good clinical application effectiveness.