睾丸中BORIS的表达和功能研究进展

BORIS expression and function in testis

印记位点调节物兄弟因子BORIS,在脊椎动物的进化过程中从羊膜动物开始出现。人正常生理状态下,该蛋白仅在男性睾丸中高表达。雄性小鼠中BORIS的表达时序与精子发生时序高度一致,BORIS基因敲除小鼠雄性不育,而雌性生长发育正常。BORIS诱导生殖细胞中特定基因的表达,在精子发生中起重要作用。BORIS在正常生理条件下特异性地调控精子发生。本文在综述近年来BORIS转基因小鼠、BORIS基因敲除小鼠、睾丸中BORIS的表达和机制研究的基础上,总结了BORIS的表达定位、BORIS对精子发生的作用机制、BORIS功能研究和靶向药物研究,为针对BORIS的分子靶向治疗提供新的参考依据。

BORIS(brother of the regulator of imprinted sites)was first expressed in amniotes during the evolution of vertebrates.Under human physiological conditions,this protein is highly expressed in male testes only.The expression sequence of BORIS in male mice is highly consistent with the sequence of spermatogenesis.Male BORIS knockout mice are sterile,while females are normal.BORIS induces the expression of specific genes in germ cells and has an important role in spermatogenesis,specifically regulating spermatogenesis under normal physiological conditions.Referring to recent studies of BORIS transgenic mice,BORIS knockout mice,and BORIS expression in testis,this review summarizes the expression and localization of BORIS in testis,the mechanism of BORIS in spermatogenesis,and the functional research and drug screening of BORIS,providing a new reference for molecular targeted therapy.