丙戊酸联合拉莫三嗪治疗癫痫的临床疗效评估

Clinical evaluation of valproic acid combined with lamotrigine in the treatment of epilepsy

目的评估丙戊酸联合拉莫三嗪治疗癫痫的临床疗效。方法选取2018年5月至2019年5月本院收治的70例癫痫患者,根据治疗方法的不同分为对照组和联合组,每组35例。对照组采用丙戊酸治疗,联合组在对照组基础上联合拉莫三嗪治疗,比较两组疾病总控制率、疾病发作频率、炎症因子水平及不良反应发生情况。结果联合组疾病总控制率高于对照组(P<0.05);治疗前,两组疾病发作频率比较差异无统计学意义;治疗后3、6个月,联合组疾病发作频率低于对照组(P<0.05)。治疗前,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)水平比较差异无统计学意义;治疗后,联合组TNF-α、IL-2水平低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论丙戊酸联合拉莫三嗪治疗癫痫效果显著,不仅可减少患者癫痫发作次数,还可降低TNF-α、IL-2水平,改善患者的炎症反应,且两种药物联合治疗的安全性较高。

Objective To evaluate the clinical efficacy of valproic acid combined with lamotrigine in the treatment of epilepsy.Methods 70 patients with epilepsy admitted to our hospital from May 2018 to May 2019 were divided into control group and combination group according to different treatment methods,with 35 cases in each group.The control group adopted valproic acid treatment,the combined group was treated with lamotrigine on the basis of the control group.The disease control rates,attack frequency,inflammatory factor levels and the incidence of adverse reactions between the two groups were compared.Results The total disease control rate of the combination group was higher than that of the control group(P<0.05).There was no significant difference in the frequency of disease attack between the two groups before treatment;the frequency of disease attack at 3 and 6 months after treatment in the combination group was less than that in the control group(P<0.05).There was no significant difference in TNF-α and IL-2 levels between the two groups before treatment;the levels of TNF-α and IL-2 in the combination group after treatment were lower than that those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Valproic acid combined with lamotrigine has significant effect on the treatment of epilepsy,which can not only reduce the number of seizures,but also reduce the levels of TNF-α and IL-2,improve the inflammatory response of patients,and the safety of the two-drug combination treatment is high.