8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物的合成与表征

Synthesis and Characterization of 8-(3-Chlorophenyl)-3-methylthio-1-phenyl-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4-one derivatives

以吡唑膦亚胺、3-氯苯基异氰酸酯和取代苯氧乙(丙)酰肼为原料,通过串联氮杂Wittig关环反应合成了6个未见文献报道的化合物8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物(■),通过核磁共振氢碳谱和HRMS等确证进行了表征。

Six novel 8-(3-chlorophenyl)-3-methylthio-1-phenyl-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4-one derivatives(■)were synthesized via tandem Aza-Wittig and annulation reactions of the iminophosphorane,3-chlorophenyl isocyanate,and substituted 2-phenoxy acetohydrazide(or 2-phenoxypropanehydrazide).Their structures were confirmed by 1H NMR,13C NMR,and HRMS.