“一锅法”合成左氧氟沙星

"One-pot"Synthesis of Levofloxacin

以左氧氟环合酯为原料,水解后直接与N-甲基哌嗪缩合反应,“一锅法”合成左氧氟沙星。该合成方法产品收率高、三废少、生产效率高,符合绿色化学理念。

Levofloxacin is synthesized by condensation reaction with N-methylpiperazine after hydrolysis with as raw material."One-pot"to synthesize levofloxacin.The synthesis method has the advantages of product yield,less three wastes,improved production efficiency,and conforms to the concept of green chemistry.