精神分裂症患者血清BDNF、MIF、EGF水平及其与认知功能的相关性

Serum BDNF,MIF,EGF Levels and their Correlation with Cognitive Function in Patients with Schizophrenia

[目的]探讨精神分裂症外周血中血清脑源性神经营养因子(BDNF).血清巨噬细胞迁移抑制因子(MIF)、表皮生长因子(EGF)水平及其与认知功能的相关性。[方法]选择2017年1月至2019年1月本院收治的54例精神分裂症患者的临床资料(观察组),另选取同期健康体检志愿者58例(对照组)。采用酶联免疫吸附试验检测两组研究对象血清BDNF、MIF、EGF水平,阳性和阴性症状量表(PANSS)对患者临床症状进行评估,认知功能成套测验共识版(MCCB)评估认知功能,同时采用Pearson直线相关性分析精神分裂症外周血中BDNF、MIF、EGF水平与认知功能关系。[结果]对照组血清BDNF水平明显高于观察组,血清MIF、EGF水平低于观察组,差异有统计学意义(P<0.05)。观察组血清MIF与其PANSS呈正相关性(r=0.286,P<0.05)。对照组连线测验评分低于观察组,符号编码、视觉记忆、言语记忆和语义流畅性均高于观察组,差异有统计学意义(P<0.05)。观察组血清MIF水平与视觉空间记忆呈正相关(r=0.485,P<0.05),EGF水平与视觉空间记忆呈正相关(r=0.331,P<0.05)。[结论]血清MIF、EGF水平与精神分裂症患者临床表现和部分认知功能障碍密切相关,且两者及其与BDNF水平也存在相关性。

[Objective]To explore the serum brain derived neurotrophic factor(BDNF).serum macrophage migration in-hibitory factor(MIF),epidermal growth factor(EGF)and their relationship with cognitive function in peripheral blood of schizophrenia.[Methods]The clinical data of 54 schizophrenic patients treated in our hospital from January 2017 to January 2019(observation group)and 58 healthy volunteers in the same period(control group)were selected.The levels of serum BDNF,MIF and EGF in the two groups were detected by enzyme-linked immunosorbent assay.The clinical symptoms were evaluated by positive and negative symptom scale(PANSS),and the cognitive function was evaluated by cognitive function package consensus Version(MCCB).At the same timp,the relationship between the levels of BDNF,MIF and EGF in peripheral blood of schizophrenia and cognitive function was analyzed by Pearson linear correlation.[Results]The levels of serum BDNF in the control group were significantly higher than those in the observation group,and the levels of serum MIF and EGF were lower than those in the observation group(P<0.05).There was a positive correlation between PAS and NSF(r=286.05,P<0.05).The score of connection test in the control group was lower than that in the observation group,and the symbol coding,visual memory,verbal memory and semantic fluency were higher than those in the observation group(P<0.05).In the observation group,serum MIF level was positively correlated with visual spatial memory(r=0.485,P<0.05),and EGF level was positively correlated with visual spatial memory(r=0.331.P<0.05).[Conclusion]The levels of serum MIF and EGF are closely related to the clinical manifestations and some cognitive impairment of schizophrenic pa tients,and they are also related to the level of BDNF.