IL-22在急性胰腺炎患者血清中的表达及意义

Expression of IL-22 in patients with acute pancreatitis and its significance

目的探讨白介素22(Interleukin-22,IL-22)在急性胰腺炎(acute pancreatitis,AP)患者血清中的表达情况及其与AP严重程度的关系;为AP患者临床诊治提供新的思路。方法选取2015年12月至2018年12月安徽医科大学第一附属医院急诊外科及EICU收治的AP患者共70例,按照最新的AP诊疗指南进行分组,采用双抗体夹心酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)测定15例重症急性胰腺炎(severe acute pancreatitis,SAP)、18例中度重症急性胰腺炎(moderately severe acute pancreatitis,MSAP)及37例轻症急性胰腺炎(mild acute pancreatitis,MAP)患者及30例健康对照受试者血清IL-22的水平。结果所有AP患者血清IL-22水平均明显高于对照组,差异有统计学意义(P<0.05);IL-22与AP病情严重程度有关,分级程度越高,患者血清IL-22水平越高;SAP组、MSAP组、MAP组及对照组各组间差异有统计学意义(P<0.05)。结论IL-22可能与AP发病发展有关;可能对AP诊治提供辅助参考。

Objective To explore the level of serum IL-22 in AP patients,and to evaluate the value of IL-22 in AP severity assessment,then may provide a new idea for clinical diagnosis and treatment of AP patients.Methods According to the latest AP di-agnosis and treatment guidelines,a total of 70 AP patients admitted to the emergency surgery department and EICU of the First Affilia-ted Hospital of Anbui Medical University from December 2015 to December 2018 were divided into groups.Detect the levels of serum IL-22 in 15 SAP patients,18 MSAP patients,37 MSAP patients and normal peoples and 30 healthy control subjects by ELISA.Re-sults The level of serum IL-22 in all AP patients are signifcantly higher than that in control group(P<0.05);The higher the severi-ty of AP,the higher the serum IL-22 level.There were significant differences between SAP group,MSAP group,MAP group and con-trol(P<0.05).Conclusion IL-22 may be associated with AP progress;It may provide the reference for the diagnosis and treatment of AP patients.