类器官模型在糖尿病研究领域的应用

The application of organoid models in diabetes research

类器官是利用干细胞的自我更新和自我组装性能,经体外三维培养形成的微小组织器官类似物。本文综述了介导血糖调控和糖尿病慢性血管并发症的组织类器官构建过程,及其在糖尿病领域中的应用进展。类器官技术在疾病建模、个体化医疗和再生医学等方面有助于进一步推进糖尿病领域的研究。

Organoids are complex tiny organ-like model systems formed by three-dimensional culture in vitro,based on the self-renew and self-organization of stem cells.This article reviewed the recent progress in organoids construction from tissues involved in the regulation of glucose homeostasis and chronic diabetic microvascular complications,and their applications in diabetes mellitus.Organoid technology is expected to further promote the progress of diabetes research in disease modeling,personalized medicine,and regenerative medicine.