苦参碱对血管的药理作用研究进展

Research Progress on Pharmacologic Effects of Matrine on Blood Vessels

苦参碱能对抗细菌内毒素、缺血再灌注和纤维蛋白纤维蛋白原降解产物对血管内皮细胞的损伤作用,也能抗血小板衍化生长因子、血管紧张素-II和氧化型低密度脂蛋白(ox LDL)诱导血管平滑肌细胞增殖和凋亡,还能抗晚期糖基化终末产物诱导血管平滑肌细胞向具有收缩性的表型转化,从而产生血管的保护作用和改善血管的功能。苦参碱还可通过阻断神经节和提高胆碱能神经作用以及促进一氧化氮合成和释放,产生降压作用,也能通过改善心功能调节血压。苦参碱能抑制野百合碱引起的肺动脉高压和肺血管重构,以及高脂饮食引起的动脉粥样硬化。文中综述苦参碱对血管的药理作用文献,并对其研究进展做了分析。

Matrine not only could counteract the damage of vascular endothelial cells induced by bacterial endotoxin,ischemia reperfusion and fibrinogen degradation products,but also could inhibit the proliferation and apoptosis of vascular smooth muscle cells induced by platelet-derived growth factor, angiotensin II and oxidized low density lipoprotein(ox LDL), and even could resist the advanced glycation end products to induce the transformation of vascular smooth muscle cells to contractile phenotype, thereby producing vascular protection and improving vascular function. Matrine has a hypotensive effect by blocking ganglia, improving cholinergic nerve action and promoting nitric oxide(NO)synthesis and release as well as improving cardiac function. In addition, matrine could inhibit monocrotaline induced pulmonary hypertension and pulmonary vascular remodeling, as well as high-fat diet induced atherosclerosis. In this paper,the literatures on the pharmacological effects of matrine on blood vessels have been reviewed, and the research progress of matrine has been analyzed.