摘要
微生物在感染宿主的过程中能够调控宿主的生理功能,其中一种重要的调控方式是表观遗传调控。表观遗传是指在基因DNA序列不发生改变的情况下,基因的表达和功能发生稳定改变,并产生可遗传的表型。表观遗传调控在微生物引起宿主免疫反应的过程中起到重要作用。明确微生物对宿主的表观遗传调控机制有利于开展临床靶向治疗,加强表观遗传调节剂的临床应用,为相关疾病防治提供新的策略。该文对几种口腔常见微生物引起的宿主表观遗传改变及相关机制作一综述。
Microbes can regulate the physiological function of infected hosts during host-microbe interaction.One of the important regulations is epigenetic regulation.Epigenetic inheritance relates to changes in gene expression and function that are not encoded in the DNA sequences and inducible heritable phenotypes.The epigenetic regulation plays an essential role in host immune response caused by microbe challenges.Clarifying the epigenetic regulation mechanisms of microbes in the host is beneficial to carry out clinical targeted therapies,enhance the clinical application of epigenetic regulators and provide new strategies for the prevention and treatment of related diseases.This review summarizes the epigenetic changes in hosts caused by several common oral microbes and related mechanisms.
作者
时小婷
潘亚萍
SHI Xiaoting;PAN Yaping(Department of Periodont antics,School and Hospital of Stomatology,China Medical University,Shenyang 110002,China)
出处
《口腔医学》
CAS
2021年第7期640-643,共4页
Stomatology
基金
国家自然科学基金(81870771)。
